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Age-related differences in the urinary excretion of prostaglandin F2α catabolites in the rat

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Summary

Tritium-labelled PGF2α was administered i.v. into rats of varying ages (2, 4, 6 weeks and adult). Urine was collected and assayed for radioactive products by thin-layer-chromatography. Results showed a distinctly different urinary profile between the 2-week-old and the adult rat. While the urinary pattern from the 2-week-old rat gave a single less polar product than PGF2α, the pattern from the adult rat gave products more polar than PGF2α. Urine from the 4- and 6-week-old rats gave a mixture of these types of products. These results indicate that some prostaglandin catabolic pathway (likely the ω-oxidative system) is activated in vivo within the 4–6-week postnatal period in the rat.

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Authors and Affiliations

  1. Research Institute, The Hospital for Sick Children, 555 University Avenue, M5G 1X8, Toronto, Canada

    C. R. Pace-Asciak, N. S. Edwards & M. C. Carrara

Authors
  1. C. R. Pace-Asciak
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  2. N. S. Edwards
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  3. M. C. Carrara
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Additional information

Supported by a grant (MT-4181) to C.P.-A. from the Medical Research Council of Canada.

This study is in partial fulfillment of the requirements for a Ph.D. degree in the Department of Pharmacology, University of Toronto.

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Pace-Asciak, C.R., Edwards, N.S. & Carrara, M.C. Age-related differences in the urinary excretion of prostaglandin F2α catabolites in the rat. Experientia 36, 635–637 (1980). https://doi.org/10.1007/BF01970104

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