Summary
Direct incorporation and cold trap experiments suggest that cholest-4-en-3-one is an intermediate in the conversion of cholesterol into 3β-hydroxymethyl-A-nor-cholestane in the marine spongeAxinella verrucosa. Cholest-4-en-3-one is further transformed by the sponge into cholest-4-en-3β-ol, 5α-cholestan-3-one and 5α-cholestan-3β-ol; these compounds arise from side reactions, which are not part of the major metabolic route leading to 3β-hydroxymethyl-A-norsteranes.
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De Stefano, A., Sodano, G. Metabolism in Porifera XII. Further informations on the biosynthesis of 3β-hydroxymethyl-A-nor-steranes in the spongeAxinella verrucosa. Experientia 36, 630–632 (1980). https://doi.org/10.1007/BF01970101
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DOI: https://doi.org/10.1007/BF01970101