, Volume 41, Issue 7, pp 930–931 | Cite as

Inhibition of virus multiplication and alteration of cyclic AMP level in cell cultures by flavonoids

  • I. Mucsi
  • B. M. Prágai
Short Communications Biochemistry and Biophysics, Metabolism, Neurobiology, Pharmacology


The inhibitory effect of four flavonoid compounds on virus multiplication and their influence on the intracellular cyclic AMP (cAMP) level were studied in cell cultures. Quercetin and quercitrin reduced the yields ofHuman (alpha) herpesvirus 1 (HSV-1) andSuid (alpha) herpesvirus 1 (pseudorabies virus), but hesperidin and rutin had no effect. Further, quercetin and quercitrin elevated the intracellular level of cAMP, whereas hesperidin and rutin did not alter the cAMP level. Both antiviral activity and cAMP-enhancing effect were dependent on the concentrations of the flavonoids, and these effects turned out to be parallel.

This study suggests that a relation exists between the antiviral effect and the cAMP-enhancing activity of flavonoids.

Key words

flavonoids cyclic AMP-enhancing activity human (alpha) herpesvirusSuid (alpha) herpesvirus


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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • I. Mucsi
    • 1
  • B. M. Prágai
    • 1
  1. 1.Institute for MicrobiologyUniversity Medical SchoolSzeged(Hungary)

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