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α-Particle track autoradiographic study of the distribution of a [211At]-astatinated drug in normal tissues of the mouse

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  • Biochemistry and Biophysics, Metabolism, Neurobiology, Pharmacology
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Summary

The microscopic distribution of the potential endoradiotherapeutic drug, 6-[211At]-astato-2-methyl-1,4-naphthoquinol bis (diphosphate salt) in normal tissues of the mouse has been studied by α-particle track autoradiography. The uptake into critical radiosensitive tissues, especially bone marrow, colon and lung, was low.

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References

  1. Acknowledgments. We are grateful to Prof. J. Walker and the staff of the Radiation Centre and Nuffield Cyclotron, Department of Physics, Birmingham University, England, and for the cooperation of Dr A.T.M. Vaughan, Department of Immunology, The Medical School, Birmingham. We are also grateful to Dr L. M. Franks of the Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London, for the supply of the original mouse tumors. We also thank Mr L.F.H. Beard and Mr M. Johns and the staff of the Department of Medical Illustration and Photography, Addenbrooke's Hospital, Hills Road, Cambridge.

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Authors and Affiliations

  1. University of Cambridge School of Clinical Medicine, Research Laboratories, Radiotherapeutic Centre, Addenbrooke's Hospital, Hills Road, CB2 2QQ, Cambridge, England

    J. S. Mitchell, I. Brown & R. N. Carpenter

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  1. J. S. Mitchell
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  2. I. Brown
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  3. R. N. Carpenter
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Mitchell, J.S., Brown, I. & Carpenter, R.N. α-Particle track autoradiographic study of the distribution of a [211At]-astatinated drug in normal tissues of the mouse. Experientia 41, 925–928 (1985). https://doi.org/10.1007/BF01970016

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  • DOI: https://doi.org/10.1007/BF01970016

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