, Volume 41, Issue 7, pp 918–919 | Cite as

The regeneration of newt limbs deformed in nature

  • P. A. Tsonis
  • G. Eguchi
Short Communications Anatomy, Physiology


The regeneration of abnormal limbs from a wild newt population was examined. The abnormalities were: mirror symmetrical reduplications of digit parts, deformed wrists, or limbs with supernumerary digits. Normal regeneration resulted after amputation of the abnormal parts, regardless of the original deformity. The results suggest that the abnormalities are probably the result of local trauma to the limbs.

Key words

Newts, wild population Cynops pyrrhogaster limb regeneration deformed limbs 


  1. 2.
    Acknowledgments. The authors wish to thank the Japanese Ministry of Education for supporting the research of P.A. Tsonis, and Ms Phyllis Minnick and Ms M. Kat Morales for assistance.Google Scholar
  2. 3.
    Bryant, S.V., French, V., and Bryant, P.J., Science212 (1981) 993.Google Scholar
  3. 4.
    Wolpert, L., J. theor Biol.25 (1969) 1.PubMedGoogle Scholar
  4. 5.
    Wolsky, A., in: Neoplasia and Differentiation, p. 153. Ed. G. V. Shebert. Karger, Basel 1974.Google Scholar
  5. 6.
    Tsonis, P.A., and Eguchi, G., Differentiation20 (1981) 52.PubMedGoogle Scholar
  6. 7.
    Tsonis, P.A., and Eguchi, G., Develop. Growth Different.24 (1982) 183.Google Scholar
  7. 8.
    Tsonis, P.A., and Eguchi, G., Develop. Growth Different.25 (1983) 201.Google Scholar
  8. 9.
    Maden, M., Nature295 (1982) 672.PubMedGoogle Scholar
  9. 10.
    Rostland, J., in: Les crapaus, les grenouilles et quelques grands problemes biologiques. Gallimard, Paris 1955.Google Scholar
  10. 11.
    Dearlove, G.E., and Dresden, M.H., J. exp Zool.196 (1976) 251.PubMedGoogle Scholar
  11. 12.
    Newth, D.R., J. Embryol. exp. Morph.6 (1958) 384.PubMedGoogle Scholar
  12. 13.
    Takaya, H., Annot. Zool.12 (1941) 181.Google Scholar
  13. 14.
    Breedis, C., Cancer Res.12 (1952) 861.PubMedGoogle Scholar
  14. 15.
    Slack, J.M.W., and Savage, S., Cell14 (1978) 1.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • P. A. Tsonis
    • 1
    • 2
  • G. Eguchi
    • 1
    • 2
  1. 1.Institute of Molecular Biology, Faculty of ScienceNagoya UniversityNagoya(Japan)
  2. 2.Department of Developmental BiologyNational Institute for Basic BiologyOkazaki(Japan)

Personalised recommendations