, Volume 36, Issue 11, pp 1309–1310 | Cite as

Effect of chronic administration of morphine on primary immune response in mice

  • M. Güngör
  • E. Genç
  • H. Saĝduyu
  • L. Eroĝlu
  • H. Koyuncuoĝlu


The effect of 3 different doses of chronically-administered morphine on the primary immune response was studied in mice by estimating spleen/body weight ratio and serum hemolysin production against sheep red blood cells (SRBC). It was observed that morphine exerted a dose-dependent inhibitory effect on the immune response which was antagonized by the concomitant administration of naloxone. The findings suggest that the inhibitory effect of morphine is specific.


Immune Response Blood Cell Morphine Weight Ratio Naloxone 
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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • M. Güngör
    • 1
  • E. Genç
    • 1
  • H. Saĝduyu
    • 1
  • L. Eroĝlu
    • 1
  • H. Koyuncuoĝlu
    • 1
  1. 1.Department of Pharmacology and Clinical Pharmacology, Istanbul Medical FacultyIstanbul UniversityIstanbul(Turkey)

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