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Intraphagocytic activity of erythromycin, roxithromycin and azithromycin

  • New Antimicrobial Agents
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European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

The intraphagocytic activity of erythromycin, roxithromycin and azithromycin against phagocytosedStaphylococcus aureus was compared. Erythromycin and roxithromycin both acted bacteriostatically at concentrations corresponding to 10×MIC. Azithromycin, however, did not prevent intracellular proliferation of the staphylococci. On comparison of the pH dependency of the antibacterial activity of the three drugs, azithromycin was found to be inactivated earlier in an acidic milieu.

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References

  1. Anderson R, van Rensburg CEJ, Joone G, Lukey PT An in vitro comparison of the intraphagocytic bioactivity of erythromycin and roxithromycin. Journal of Antimicrobial Chemotherapy 1987, 20, Supplement B: 57–68.

    Google Scholar 

  2. Carlier MB, Zenebergh A, Tulkens PM Cellular uptake and subcellular distribution of roxithromycin and erythromycin in phagocytic cells. Journal of Antimicrobial Chemotherapy 1987, 20, Supplement B: 47–56.

    Google Scholar 

  3. Gladue RP, Bright GM, Isaacson RE, Newborg MF In vitro and in vivo uptake of azithromycin (CP-62, 993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrobial Agents and Chemotherapy 1989, 33: 277–282.

    PubMed  Google Scholar 

  4. Vildé JL, Dournon E, Rajagopalan P Inhibition ofLegionella pneumophila multiplication within human macrophages by antimicrobial agents. Antimicrobial Agents and Chemotherapy 1986, 30: 743–748.

    PubMed  Google Scholar 

  5. Rodgers FG, Elliot TSJ Antibiotic killing of legionella. Lancet 1984, i: 683–684.

    Article  Google Scholar 

  6. Horwitz MA, Silverstein SC Intracellular multi-plication of Legionnaire's disease bacteria (Legionella pneumophila) in human monocytes is reversibly inhibited by erythromycin and rifampicin. Journal of Clinical Investigation, 1983, 71: 15–26.

    PubMed  Google Scholar 

  7. Vosbeck K, James PR, Zimmermann W Antibiotic action on phagocytosed bacteria measured by a new method for determining viable bacteria. Antimicrobial Agents and Chemotherapy 1984, 25: 735–741.

    PubMed  Google Scholar 

  8. Hand WL, King-Thompson NL Contrasts between phagocyte antibiotic uptake and subsequent intracellular bactericidal activity. Antimicrobial Agents and Chemotherapy 1986, 29: 135–140.

    PubMed  Google Scholar 

  9. Hand WL, King-Tompson NL, Holman JW Entry of roxithromycin (RU 965), imipenem, cefotaxime, trimethoprim and metronidazole into human polymorphonuclear leukocytes. Antimicrobial Agents and Chemotherapy 1987, 31: 1553–1557.

    PubMed  Google Scholar 

  10. Bermudez LEM, Young LS Activities of amikacin, roxithromycin, and azithromycin alone and in combination with tumor necrosis factor againstMycobacterium avium complex, Antimicrobial Agents and Chemotherapy 1988, 32: 1149–1153.

    PubMed  Google Scholar 

  11. Chang HR, Pechère JCF In vitro effects of four macrolides (roxithromycin, spiramycin, azithromycin [CP-62, 993] and A-56268) onToxoplasma gondii. Antimicrobial Agents and Chemotherapy 1988, 32: 524–529.

    PubMed  Google Scholar 

  12. Milatovic D. Effect of subinhibitory antibiotic concentrations on the phagocytosis ofStaphylococcus aureus. European Journal of Clinical Microbiology 1982, 1: 97–101.

    PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Medical Microbiology, Technical University Munich, Trogerstraße 32, 8000, Munich 80, FRG

    D. Milatovic

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  1. D. Milatovic
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Milatovic, D. Intraphagocytic activity of erythromycin, roxithromycin and azithromycin. Eur. J. Clin. Microbiol. Infect. Dis. 9, 33–35 (1990). https://doi.org/10.1007/BF01969530

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