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Agents and Actions

, Volume 30, Issue 1–2, pp 198–201 | Cite as

Ischemia reperfusion injury and histamine release in isolated and perfused guinea-pig heart: Pharmacological interventions

  • E. Masini
  • S. Bianchi
  • F. Gambassi
  • B. Palmerani
  • A. Pistelli
  • L. Carlomagno
  • P. F. Mannaioni
Histamine and the Gastrointestinal Tract and Cardiovascular System

Abstract

Experiments were carried out to provide further information on the biochemical and morphological changes occurring in the guinea-pig heart after multiple ligature and reopening of the left anterior descending (LAD) coronary artery. In isolated perfused guinea-pig heart the reopening of LAD coronary artery leads to a release of histamine related to a loss of metachromasia by cardiac mast cells. The process is associated with malonyldialdehyde (MDA) production, cellular overload of calcium and ventricular arrhythmias which can be modulated by pharmacological interventions.

Keywords

Calcium Coronary Artery Ischemia Mast Cell Histamine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1990

Authors and Affiliations

  • E. Masini
    • 1
  • S. Bianchi
    • 2
  • F. Gambassi
    • 1
  • B. Palmerani
    • 1
  • A. Pistelli
    • 1
  • L. Carlomagno
    • 1
  • P. F. Mannaioni
    • 1
  1. 1.Department of Preclinical and Clinical PharmacologyUniversity of FlorenceFlorenceItaly
  2. 2.Department of Animal BiologyUniversity of FlorenceFlorenceItaly

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