Agents and Actions

, Volume 30, Issue 1–2, pp 134–136 | Cite as

Influence of TMB-8 and calmidazolium on phorbol ester promoted histamine release from isolated rat mast cells

  • N. Grosman
  • J. K. Nielsen
Histamine Release


The effects of TMB-8 and calmidazolium were investigated on mast cell responses believed to be mediated by protein kinase C, i.e. histamine release induced by TPA (tetradecanoyl-phorbol-acetate) in combination with sub-threshold concentrations of the ionophore A23187 and with antigen. Inhibition with both drugs was found in the same concentration range as observed earlier and could be counteracted by glucose, indicating an impaired oxidative energy production. Hence, the test drugs do not reveal protein kinase C selectivity.


Glucose Ester Protein Kinase Mast Cell Histamine 
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Copyright information

© Birkhäuser Verlag 1990

Authors and Affiliations

  • N. Grosman
    • 1
  • J. K. Nielsen
    • 1
  1. 1.Department of PharmacologyUniversity of CopenhagenCopenhagen ØDenmark

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