Histamine secretion from mast cells stimulated with bradykinin
- 78 Downloads
Bradykinin and a range of peptide analogues induced a dose-dependent release of histamine from rat peritoneal mast cells. The characteristics of the release were not consistent with the involvement of defined bradykinin receptors but indicated that the peptide acted through the putative mast cell polyamine receptor. Consistently, the effect of bradykinin was largely confined to serosal mast cells of the rat and hamster, while human histaminocytes were essentially unresponsive. These data do then not support a general role for kinin-induced activation of mast cells in human allergic disease.
KeywordsPeptide Mast Cell Histamine Bradykinin Allergic Disease
Unable to display preview. Download preview PDF.
- R. W. Fuller, C. M. S. Dixon, F. M. C. Cuss and P. J. Barnes,Bradykinin-induced bronchoconstriction in humans. Am. Rev. respir. Dis.135, 176–180 (1986).Google Scholar
- G. W. Read, S. M. Hong and E. F. Kiefer,Competitive inhibition of 48/80-induced histamine release by benzalkonium chloride and its analogs and the polyamine receptor in mast cells. J. Pharmac. exp. Ther.222, 652–657 (1982).Google Scholar