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, Volume 22, Issue 1–2, pp 43–49 | Cite as

Effects of low molecular weight fibrin degradation products 6A and 6D on rabbit aorta strips

  • F. Marceau
  • J. Bouthillier
  • B. Tremblay
  • S. St.-Pierre
Histamine and Kinins

Abstract

Two small molecular weight fibrin degradation product, the pentapeptide 6A and the undecapeptide 6D, produced relaxations of norepinephrine-contracted rabbit aorta strips. The relaxations were slow-developing and were elicited by both peptides at supramicromolar concentrations; the amplitude of relaxations were small for 6D. The relaxations induced by 6A were not dependent on the presence of endothelium and were not modified by a mixture of indomethacin, pyrilamine, and cimetidine. The amplitude of the relaxations produced by 6A and 6D increased as a function of incubation timein vitro.

In another experimental system, peptides 6A and 6D failed to increase 6-keto-PGF release from cultured human umbilical endothelial cells. Histamine and bradykinin were both active in this system.

Keywords

Peptide Molecular Weight Endothelial Cell Histamine Indomethacin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1987

Authors and Affiliations

  • F. Marceau
    • 1
  • J. Bouthillier
    • 1
  • B. Tremblay
    • 1
  • S. St.-Pierre
    • 2
  1. 1.Unité de Recherche sur l'Inflammation et en Immunologie et RhumatologieC.H.U.L.Canada
  2. 2.INRS-SantéPavillon GamelinMontréalCanada

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