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The bactericidal activity of aqueous disinfectants applied on living tissues

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Abstract

Thirteen antiseptic aqueous solutions intended for the disinfection of living tissues were compared in regard to their microbicidal effectiveness towardsStaphylococcus aureus andPseudomonas aeruginosa. Six antiseptics, which contain boric acid, eosine, hydrogen peroxide or an organic mercury compound as the active substance, did not fulfil the requirements of the preliminaryin vitro test. The seven other preparations were examined in a practical test, in which bactericidal activity was assessed on artificially contaminated intact skin after exposures of 15 s and 60 s. The most active solution appeared to be 0.5% tosylchloramide sodium, followed by 0.05% chlorhexidine with 0.5% cetrimide. The other preparations, namely 0.05% chlorhexidine without cetrimide, 0.245% chloroxylenol, 0.04% clorofene, 10% povidone-iodine and 0.2% tosylchloramide sodium, were less active in this practical test.

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References

  1. Reybrouck G. The evaluation of the antimicrobial activity of disinfectants. In: Russel AD, Ayliffe GAJ, Hugo WB, eds. Principles and practice of disinfection, preservation and sterilization. Oxford: Blackwell Scientific Publications, 1981:134–57.

    Google Scholar 

  2. Charrel J, Gevaudan M-J, Mallet M-N, Blancard A, Gevaudan P. Evaluation du pouvoir bactéricide de huit antiseptiques destinés au lavage de type chirurgical des mains. Rev Epidém Santé Publ 1977;25:297–313.

    Google Scholar 

  3. Wewalka G, Rotter M, Koller W, Stanek G. Wirkungsvergleich von 14 Verfahren zur Hygienischen Händedesinfektion. Zbl Bakt Hyg, I Abt Orig B 1977;165: 242–9.

    Google Scholar 

  4. Crémieux A, Guiraud-Dauriac H, Cazac JL, Plumelle Y, Dumenil G. Etude comparative de l'activité antimicrobienne de plusieurs antiseptiques en deux sites cutanés. Rev Instit Pasteur Lyon 1978;11:523–33.

    Google Scholar 

  5. Davies J, Babb JR, Ayliffe GAJ, Wilkins MD. Disinfection of the skin of the abdomen. Br J Surg 1978;65:855–8.

    PubMed  Google Scholar 

  6. Ayliffe GAJ. The effect of antibacterial agents on the flora of the skin. J Hosp Infect 1980;1:111–24.

    Article  PubMed  Google Scholar 

  7. Ritter MA, French MLV, Eitzen HE, Gioe TJ. The antimicrobial effectiveness of operative-site preparative agents. J Bone Joint Surg 1980;62-A:826–8.

    Google Scholar 

  8. Beignot-Devalmont M, Sébastien F, Bernard J, Desvignes A. Etude comparative de l'activité antimicrobiennein vitro etin vivo de sept solutions destinées à l'antisepsie de la peau. Ann Pharm Fr 1981;39:147–53.

    PubMed  Google Scholar 

  9. Kaul AF, Jewett JF. Agents and techniques for disinfection of the skin. Surg Gynecol Obstet 1981;152:677–85.

    PubMed  Google Scholar 

  10. Reybrouck G, Werner H-P. Ausarbeitung eines neuen quantitativen in-vitro Tests für die bakteriologische Prüfung chemischer Desinfektionsmittel. Zbl Bakt Hyg, I Abt Orig B 1977;165:126–37.

    Google Scholar 

  11. Reybrouck G. Efficacy of inactivators against 14 disinfectant substances. Zbl Bakt Hyg, I Abt Orig B 1979;168:480–92.

    Google Scholar 

  12. Skornik WA, Dressler DP. Topical antisepsis studies in the burned rat. Arch Surg 1971;103:469–74.

    PubMed  Google Scholar 

  13. Stieritz DD, Bondi A, McDermott D, Michaels EB. A burned mouse model to evaluate anti-pseudomonas activity of topical agents. J Antimicrob Chemother 1982;9:133–40.

    Google Scholar 

  14. Dhingra U, Schauerhamer RR, Wangensteen OH. Peripheral dissemination of bacteria in contaminated wounds; role of devitalized tissue: evaluation of therapeutic measures. Surgery 1976;80:535–43.

    PubMed  Google Scholar 

  15. Byatt ME, Henderson A. Preoperative sterilization of the perineum: a comparison of six antiseptics. J Clin Pathol 1973;26:921–4.

    PubMed  Google Scholar 

  16. Marples RR, Kligman AM. Methods for evaluating topical antibacterial agents on human skin. Antimicrob Agents Chemother 1974;5:323–9.

    PubMed  Google Scholar 

  17. Leyden JJ, Stewart R, Kligman AM. Updatedin vivo methods for evaluating topical antimicrobial agents on human skin. J Invest Dermatol 1979;72:165–70.

    Article  PubMed  Google Scholar 

  18. Reybrouck G. Antiseptic drugs and disinfectants. In: Dukes MNG, ed. Side Effects of Drugs Annual 5. Amsterdam: Excerpta Medica, 1981:254–9.

    Google Scholar 

  19. Reybrouck G. Antiseptic drugs and disinfectants. In: Dukes MNG, ed. Side Effects of Drugs Annual 8. Amsterdam: Elsevier Science Publishers, 1984:243–7.

    Google Scholar 

  20. Baldry MGC. The bactericidal, fungicidal and sporicidal properties of hydrogen peroxide and peracetic acid. J Appl Bacteriol 1983;54:417–23.

    PubMed  Google Scholar 

  21. Rutala WA, Cole EC. Antiseptics and disinfectants — safe and effective? Infect Contr 1984;5:215–8.

    Google Scholar 

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  1. Public Health Laboratory, School of Public Health, Catholic University of Leuven, Vital Decosterstraat 102, 3000, Leuven, Belgium

    G. Reybrouck

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  1. G. Reybrouck
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Reybrouck, G. The bactericidal activity of aqueous disinfectants applied on living tissues. Pharmaceutisch Weekblad Scientific Edition 7, 100–103 (1985). https://doi.org/10.1007/BF01968710

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  • DOI: https://doi.org/10.1007/BF01968710

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