Skip to main content
SpringerLink
Log in

Concerning the pharmacological activity of non-steroid anti-inflammatory drugs: Is the acidic function essential?

  • Histamine and Kinins Immunosuppression and Inflammation
  • Published:
Agents and Actions Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. J. S. Nicholson andS. S. Adams,Anti-Inflammatory Agents, British Patent No. 971,700 (Publ. 30 September) (1964).

  2. I. T. Harrison, B. Lewis, P. Nelson, W. Rooks, A. Roszkowski, A. Tomolonis andJ. H. Fried,Nonsteroidal Anti-Inflammatory Agents I. 6-substituted 2-Naphthylacetic acids, J. Med. Chem.13, 203–205 (1970).

    Article  PubMed  Google Scholar 

  3. M. W. Whitehouse,Evaluation of Potential Antirheumatic Drugs in vitro Using Lymphocytes and Epithelial Cells. The Selective Action of Indoxole, Methyl Glyoxal and Chloroquine, J. Pharm. Pharmac.19, 590–595 (1967).

    Google Scholar 

  4. J. P. Famaey andM. W. Whitehouse,The Effect of Non Steroidal Anti-Inflammatory Drugs on Calcium Uptake by Lymphoid Cells, Biochem. Pharmac., accepted for publication.

  5. J. P. Famaey andJ. Möckel,The Importance of Sulfhydryl Groups for the Uncoupling Activity of Non Steroidal Acidic Anti-Inflammatory Drugs and Valinomycin in Oxidative Phosphorylation, Biochem. Pharmac.22, 1487–1498 (1973).

    Article  Google Scholar 

  6. L. M. Pachman, N. B. Esterly andR. D. A. Peterson,Effect of Salicylate on the Metabolism of Normal and Stimulated Human Lymphocytes in vitro, J. clin. Invest.50, 226–230 (1971).

    PubMed  Google Scholar 

  7. J. R. Vane,Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-Like-Drugs, Nature New Biol.231, 232 (1971).

    PubMed  Google Scholar 

  8. M. Hichens,Molecular and Cellular Pharmacology o the Anti-Inflammatory Drugs: Some in vitro Properties Related to Their Possible Modes of Action, in:Anti-Inflammatory Agents (Eds. R. A. Scherrer and M. W. Whitehouse; Academic Press, New York), in press.

  9. I. F. Skidmore andM. W. Whitehouse,Biochemical Properties of Anti-Inflammatory Drugs X. Inhibition of Serotonin Formation in vitro and Inhibition of the Esterase Activity of α-Chymotrypsin, Biochem. Pharmac.16, 737–751 (1967).

    Article  Google Scholar 

  10. J. N. McArthur, M. J. H. Smith andP. C. Freeman,Anti-Inflammatory Substance in Human Serum, J. Pharm. Pharmac.24, 669–671 (1972).

    Google Scholar 

  11. M. W. Whitehouse,Biochemical Studies of Flumefenine. HCl (R-760), a Novel Anti-Inflammatory Drug, Proc. W. Pharmac. Soc.14, 55–57 (1971).

    Google Scholar 

  12. L. Levy andD. McClure,R-760 (Flazalone) a New and Unique Anti-Inflammatory Agent, Proc. W. Pharmac. Soc.15, 229–232 (1972).

    Google Scholar 

  13. M. D. Draper, F. J. Petracek, M. W. Klohs, D. A. McClure, L. Levy andO. N. Ré,Flazalone: a Novel Non-Steroidal Anti-Inflammatory Agent, Arzneimittelforschung22, 1803–1805 (1972).

    Google Scholar 

Download references

Author information

Author notes

  1. M. W. Whitehouse

    Present address: Department of Experimental Pathology, John Curtin School of Medical Research, The Australian National University, 2600, Canberra, A.C.T., Australia

  2. J. P. Famaey

    Present address: Laboratory of Pharmacology, Rheumatology Unit, School of Medicine, Free University of Brussels (U.L.B.), Brussels, Belgium

Authors and Affiliations

  1. Department of Medicine, University of California, School of Medicine, Los Angeles, California

    M. W. Whitehouse & J. P. Famaey

Authors
  1. M. W. Whitehouse
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. P. Famaey
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Whitehouse, M.W., Famaey, J.P. Concerning the pharmacological activity of non-steroid anti-inflammatory drugs: Is the acidic function essential?. Agents and Actions 3, 217–220 (1973). https://doi.org/10.1007/BF01968545

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01968545

Keywords

Search

Navigation