, Volume 35, Issue 6, pp 809–811 | Cite as

Choleretic and cholestatic effects of infused bile salts in the rat

  • R. Drew
  • B. G. Priestly


In rats, at low infusion rates taurocholate (TC), taurochenodeoxycholate (TCDC) and taurodeoxycholate (TCD) each produced an increase in bile flow of 20–50%. However, at high infusion rates (5–20 μmoles min−1 kg−1) the cholestatic effects of the bile salts were revealed and the relative toxicity of the bile salts was seen to be TDC>TCDC>TC.


Toxicity Infusion Rate Bile Salt High Infusion Bile Flow 
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Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • R. Drew
    • 1
  • B. G. Priestly
    • 1
  1. 1.Department of Human Physiology and PharmacologyThe University of AdelaideAdelaide

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