Advertisement

Experientia

, Volume 35, Issue 6, pp 809–811 | Cite as

Choleretic and cholestatic effects of infused bile salts in the rat

  • R. Drew
  • B. G. Priestly
Article

Summary

In rats, at low infusion rates taurocholate (TC), taurochenodeoxycholate (TCDC) and taurodeoxycholate (TCD) each produced an increase in bile flow of 20–50%. However, at high infusion rates (5–20 μmoles min−1 kg−1) the cholestatic effects of the bile salts were revealed and the relative toxicity of the bile salts was seen to be TDC>TCDC>TC.

Keywords

Toxicity Infusion Rate Bile Salt High Infusion Bile Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 2.
    G. Neale, B. Lewis, V. Weaver and D. Panveliwalla, Gut12, 145 (1971).PubMedGoogle Scholar
  2. 3.
    H. Popper and F. Schaffner, Human Path.1, 1 (1970).Google Scholar
  3. 4.
    G.L. Plaa and B.G. Priestly, Pharmac. Rev.28, 207 (1976).Google Scholar
  4. 5.
    C.D. Klaassen, Am. J. Physiol.220, 667 (1971).PubMedGoogle Scholar
  5. 6.
    S. Erlinger and D. Dhumeaux, Gastroenterology66, 281 (1974).Google Scholar
  6. 7.
    N.B. Javitt, New Engl. J. Med.295, 1464 (1976).PubMedGoogle Scholar
  7. 8.
    CD. Klaassen, Eur. J. Pharmac.23, 270 (1973).Google Scholar
  8. 9.
    N. Javitt and S. Emerman, J. clin. Invest.47, 1002 (1968).PubMedGoogle Scholar
  9. 10.
    B.G. Priestly, M.G. Coté and G.L. Plaa, Can. J. Physiol. Pharmac.49, 1078 (1971).Google Scholar
  10. 11.
    M.M. Fisher, R. Magnusson and K. Miyai, Lab. Invest.25, 88 (1971).PubMedGoogle Scholar
  11. 12.
    R. Herz, G. Paumgartner and R. Preisig, Scand. J. Gastroent.11, 741 (1976).PubMedGoogle Scholar
  12. 13.
    J. Reichen and G. Paumgartner, Gastroenterology68, 132 (1975).PubMedGoogle Scholar
  13. 14.
    J. Reichen and G. Paumgartner, Am. J. Physiol.231, 734 (1976).PubMedGoogle Scholar
  14. 15.
    G. Paumgartner, K. Sauter, H.P. Schwarz and R. Herz, in: The Liver. Quantitative aspects of structure and function, p. 337. Karger, Basel 1973.Google Scholar
  15. 16.
    G. Paumgartner, R. Herz, K. Sauter and H.P. Schwarz, Naunyn-Schmiedeberg's Arch. Pharmac.285, 165 (1974).Google Scholar
  16. 17.
    R.D. Adler, F-J. Wannagat and R.K. Ockner, Gastroenterology73, 129 (1977).Google Scholar
  17. 18.
    R.H. Palmer, in: Bile Salt Metabolism, p. 184. C.C. Thomas, Springfield, Ill., 1969.Google Scholar
  18. 19.
    B. Nemchausky, D. Reno and J.L. Boyer, Clin. Res.23, 254A (1975).Google Scholar
  19. 20.
    F. Hutterer, P.G. Bacchin, H. Denk, J.B. Schenkman, F. Schaffner and H. Popper, Life Sci.9, 1159 (1970).Google Scholar
  20. 21.
    F. Hutterer, H. Denk, P.G. Bacchin, J.B. Schenkman, F. Schaffner and H. Hopper, Life Sci.9, 877 (1970).Google Scholar
  21. 22.
    F. Schaffner and H. Popper, Lancet2, 355 (1969).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • R. Drew
    • 1
  • B. G. Priestly
    • 1
  1. 1.Department of Human Physiology and PharmacologyThe University of AdelaideAdelaide

Personalised recommendations