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Experientia

, Volume 35, Issue 6, pp 796–797 | Cite as

Anticonvulsant action of YG 19-256 in baboons with photosensitive epilepsy

  • B. S. Meldrum
  • R. W. Horton
Article

Summary

YG 19-256, 4-(1,3,4,9b-tetrahydro-5 methyl-2H-indeno[1,2-c]pyridine-2-yl)-2-butanone methane sulphonate, 1–3 mg/kg i.v., abolished or reduced photically-induced myoclonic responses for 1.5–6.5 h in baboons,Papio papio, without producing signs of acute neurological toxicity.

Keywords

Methane Toxicity Sulphonate Anticonvulsant Action Butanone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 2.
    D.M. Loew and P. Zwirner, Psychopharmacology26, suppl. 54 (1972).Google Scholar
  2. 3.
    P.P. Zwirner, R.D. Porsolt and D.M. Loew, Psychopharmacology45, 133 (1975).Google Scholar
  3. 4.
    D.M. Loew and R.W. Griffith, personal Communication 1972.Google Scholar
  4. 5.
    K.F. Killam, E.K. Killam and R. Naquet, Electroenceph. clin. neurophysiol.22, 467 (1967).Google Scholar
  5. 6.
    R. Naquet and B.S. Meldrum, in: Experimental Models of Epilepsy, p. 373. Ed. D. Purpura, J.K. Penry, D.B. Tower, D.M. Woodbury and R.D. Walter. Raven Press, New York 1972.Google Scholar
  6. 7.
    B.S. Meldrum, R.W. Horton and P.A. Toseland, Arch. Neurol.32, 289 (1975).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • B. S. Meldrum
    • 1
  • R. W. Horton
    • 1
  1. 1.Department of NeurologyInstitute of PsychiatryLondonEngland

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