Experientia

, Volume 35, Issue 6, pp 759–762 | Cite as

Hageman factor activation and tight junction disruption in mice challenged with attenuated endotoxin

  • R. I. Walker
  • M. Porvaznik
  • June E. Egan
  • A. M. Miller
Article

Summary

Endotoxin treated with chromium chloride is less toxic to mice than the parent molecule, but can disrupt intestinal permeability barriers and has an enhanced ability to activate Hageman factor.

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References

  1. 2.
    S.J. Prigal, A. Herp and J. Gerstein, J. Reticuloend. Soc.14, 250 (1973).Google Scholar
  2. 3.
    S.L. Snyder, R.I. Walker, T.J. McVittie and J.M. Sheil, Can. J. Microbiol., in press (1978).Google Scholar
  3. 4.
    O.D. Ratnoff, in: Immunobiology, p. 135. Ed. R.A. Good and D.W. Fisher, Sinauer Associates Inc., Stanford 1971.Google Scholar
  4. 5.
    J.W. Mason, U. Kleeberg, P. Dolan and R.W. Colman, Ann. intern. Med.73, 545 (1970).PubMedGoogle Scholar
  5. 6.
    H.R. Kimball, K.L. Melmon and S.M. Wolff Proc. Soc. exp. Biol. Med.139, 1078 (1972).PubMedGoogle Scholar
  6. 7.
    R.I. Walker and M. Porvaznik, Infect. Immun., in press (1978).Google Scholar
  7. 8.
    D.T. Caridis, M. Ishiyama, P.W.H. Woodruff and J. Fine, J. Reticuloend. Soc.14, 513 (1973).Google Scholar
  8. 9.
    C.B. Galley, R.I. Walker, G.D. Ledney and M.R. Gambrill, Exptl Hemat.3, 13 (1975).Google Scholar
  9. 10.
    R.M. Hardisty and J.C. Macpherson, Thromb. Diath. haemorrh.7, 215 (1962).PubMedGoogle Scholar
  10. 11.
    P. Klir, J. Pospisil, E. Skala, Z. Dienstbier and O. Tacheci, Strahlentherapie146, 713 (1973).PubMedGoogle Scholar
  11. 12.
    J. Aznar, J. Mayans and J.A. Aznar, Haemostasis3, 20 (1974).PubMedGoogle Scholar
  12. 13.
    R.I. Walker, S.L. Snyder, P.Z. Sobocinski, K.F. McCarthy and J.E. Egan, Can. J. Microbiol., in press (1978).Google Scholar
  13. 14.
    E. Suter, in: Bacterial Endotoxin. Ed. M. Landy and W. Braun. Institute of Microbiology, New Brunswick, NJ, 1964.Google Scholar
  14. 15.
    R.I. Walker, G.D. Ledney and C.B. Galley, Radiat. Res.62, 242 (1975).PubMedGoogle Scholar
  15. 16.
    D.C. Morrison and C. Cochrane, J. exp. Med.140, 797 (1974).PubMedGoogle Scholar
  16. 17.
    S.D. Revak and C.G. Cochrane, Thromb. Haemostasis3, 520 (1976).Google Scholar
  17. 18.
    D.M. Zubairov and L.G. Popova, Thromb. Res.8, 587 (1976).PubMedGoogle Scholar
  18. 19.
    R.G. Lerner, S.I. Rapaport and J.M. Spitzer, Thromb. Diath. haemorrh.20, 430 (1968).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • R. I. Walker
    • 1
    • 2
  • M. Porvaznik
    • 1
    • 2
  • June E. Egan
    • 1
    • 2
  • A. M. Miller
    • 1
    • 2
  1. 1.Experimental Hematology DepartmentArmed Forces Radiobiology Research InstituteBethesdaUSA
  2. 2.Veterinary Medicine DepartmentArmed Forces Radiobiology Research InstituteBethesdaUSA

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