, Volume 35, Issue 6, pp 744–746 | Cite as

Absence of dopamine sensitive adenylate cyclase in the A10 region, the origin of mesolimbic dopamine neurones

  • H. P. Lorez
  • W. P. Burkard


Dopamine (DA) failed to stimulate the adenylate cyclase of the mesolimbic A10 DA nerve cell body area, in contrast to its activating effect in the nigrostriatal A9 DA cell body area. The enzyme was stimulated by GMPPNP (a GTP analog) and NaF. This indicates the absence in the A10 cell area of DA receptors with functional coupling on adenylate cyclase, in contrast to the A9 cell area where such DA receptors are believed to be located on afferent axon terminals.


Dopamine Nerve Cell Adenylate Cyclase Activate Effect Cell Area 
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Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • H. P. Lorez
    • 1
  • W. P. Burkard
    • 1
  1. 1.Department of Pharmaceutical ResearchF. Hoffmann-La Roche & Co. LtdBaselSwitzerland

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