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Comparative antimicrobial activity of the new macrolides againstBorrelia burgdorferi

  • New Antimicrobial Agents
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Abstract

The in vitro and in vivo activity of the new macrolides azithromycin, clarithromycin and roxythromycin was compared with that of erythromycin againstBorrelia burgdorferi. In in vitro tests using ten clinical isolates all macrolides were highly active againstBorrelia burgdorferi (MIC90 0.015–0.06 µg/ml). Azithromycin was more potent than the other macrolides in experimental animal infection, eradicating the organism in all animals tested at a dosage of 8 mg/kg.

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Authors and Affiliations

  1. Max von Pettenkofer Institute for Hygiene and Medical Microbiology, University of Munich, Pettenkoferstr. 9a, 8000, München 2, FRG

    V. Preac-Mursic, B. Wilske, G. Schierz, E. Süß & B. Groß

Authors
  1. V. Preac-Mursic
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  2. B. Wilske
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  3. G. Schierz
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  4. E. Süß
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  5. B. Groß
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Preac-Mursic, V., Wilske, B., Schierz, G. et al. Comparative antimicrobial activity of the new macrolides againstBorrelia burgdorferi . Eur. J. Clin. Microbiol. Infect. Dis. 8, 651–653 (1989). https://doi.org/10.1007/BF01968150

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  • DOI: https://doi.org/10.1007/BF01968150

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