In vitro activity of cefoperazone-sulbactam combinations against cefoperazone-resistant clinical bacterial isolates
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From July 1987 to January 1988, 452 cefoperazone-resistant bacterial isolates were identified among strains subjected to routine susceptibility testing in a clinical microbiology laboratory. The 452 isolates were tested for susceptibility to cefoperazone, sulbactam, and a 2:1 combination of these drugs by agar dilution techniques. The greatest benefit of the cefoperazone-sulbactam combination was noted againstBacteroides spp. andAcinetobacter spp. The combination demonstrated clinically significant synergism against approximately 20% of strains ofPseudomonas aeruginosa.
KeywordsInternal Medicine Agar Bacterial Isolate Susceptibility Testing Great Benefit
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