Abstract
A total of 112Staphylococcus aureus strains resistant to methicillin and gentamicin were collected from 31 centres in 22 countries worldwide. Many strains were multi-resistant. In tests to determine the susceptibility of the organisms to ciprofloxacin 16 strains (14.3%), originating from France, the FRG, Israel and Italy, were shown to be resistant to this agent. To limit ciprofloxacin resistance, a reappraisal is necessary of fluoroquinolone usage against methicillin-and gentamicin-resistantStaphylococcus aureus.
Similar content being viewed by others
References
Maple, P. A. C., Hamilton-Miller, J. M. T., Brumfitt, W. World-wide antibiotic resistance in methicillin-resistantStaphylococcus aureus. Lancet 1989, i: 537–540.
Smith, S. M., Eng, R. H. K. Activity of ciprofloxacin against methicillin-resistantStaphylococcus aureus. Antimicrobial Agents and Chemotherapy 1985, 27: 688–691.
Isaacs, R. D., Kunke, P. J., Cohen, R. L., Smith, J. W. Ciprofloxacin resistance in epidemic methicillin-resistantStaphylococcus aureus. Lancet 1988, ii: 843.
Jean-Pierre, H., Boyer, G., Darbas, H. Evolution de la résistance desStaphylococcus aureus a la pefloxacin. Etude portant sur 782 souches isolées en 1985 et 1986. Pathologie Biologie 1988, 36: 956–958.
Schaefler, S. Methicillin-resistant strains ofStaphylococcus aureus resistant to quinolones. Antimicrobial Agents and Chemotherapy 1989, 27: 335–336.
Putland, R. A., Guinness, M. D. G. Autobac susceptibility testing of methicillin-resistantStaphylococcus aureus isolated in an Australian hospital. Journal of Clinical Microbiology 1985, 22: 822–827.
Milne, F. M., Faiers, M. C. Ciprofloxacin resistance in epidemic methicillin-resistantStaphylococcus aureus. Lancet 1988, ii: 843.
Mulligan, M. E., Ruane, P. J., Johnston, L., Wong, P., Wheelock, J. P., MacDonald, K., Reinhardt, J. F., Johnson, C. C., Statner, B. B., Blomquist, I., McCarthy, J., O'Brien, W., Gardner, S., Hammer, L., Citron, D. M. Ciprofloxacin for eradication of methicillin-resistantStaphylococcus aureus colonization. American Journal of Medicine 1987, 82, Supplement 4A: 215–219.
Smith, S. M., Eng, R. H. K., Berman, E. The effect of ciprofloxacin on methicillin-resistantStaphylococcus aureus. Journal of Antimicrobial Chemotherapy 1986, 17: 287–295.
Smith, J. T. Mode of action of the 4-quinolone antibacterial agents. In: Ciprofloxacin product monograph. ADIS Press, Auckland, New Zealand, 1986, p. 19–31.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Maple, P., Hamilton-Miller, J. & Brumfitt, W. Ciprofloxacin resistance in methicillin-and gentamicin-resistantStaphylococcus aureus . Eur. J. Clin. Microbiol. Infect. Dis. 8, 622–624 (1989). https://doi.org/10.1007/BF01968141
Issue Date:
DOI: https://doi.org/10.1007/BF01968141