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, Volume 9, Issue 5–6, pp 527–533 | Cite as

Therapeutic effect, ofβ-[1-phenyl-5-bis(β-chloroethyl)-amino-benzimidazolyl-(2)-Dl-alanin (ZIMET 3164) on immune complex nephritis of NZB hyhrid mice

  • J. Güttner
Immunosuppression and Inflammation
  • 12 Downloads

Abstract

β-[1-Phenyl-5-bis(β-chloroethyl)-amino-benzimid-azolyl-(2)]-Dl-alanin (ZIMET 3164), a highly immuno-suppressive but moderately cytostatic agent, was found to be able to prevent the progression of spontaneous murine immune complex nephritis in a dose-dependent fashion. For experiments, BCG-stimulated conventional female (NMRI×NZB)F1 mice suffering from rapidly progressive nephritis, BCG-stimulated and unilaterally nephrectomized (NMRI×NZB)F1 females, and (AB/Jena×NZB)F1 females characterized by a prolonged course of the disease were used. The beneficial effect was quantified by fluorescence photometry and histometry, and semiquantitatively detected by estimation of the extent of damage of individual glomerular structures when histometric methods were unsuited. Treatment of young adult animals characterized by slight to moderate glomerular lesions was more effective than of older ones with advanced nephritis. At equi-immunosuppressive dose levels ZIMET 3164 was about twice as effective as the reference substance cyclophosphamide.

Keywords

Cyclophosphamide Therapeutic Effect Dose Level Nephritis Adult Animal 
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Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • J. Güttner
    • 1
  1. 1.Forschungszentrum für Molekularbiologie und Medizin, Zentralinstitut für Mikrobiologie und Experimentelle, TherapieAkademie der Wissenschaften der DDRJena

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