Agents and Actions

, Volume 9, Issue 5–6, pp 483–487 | Cite as

Aspirin, salicylate and prostaglandins

  • M. J. H. Smith
  • A. W. Ford-Hutchinson
  • J. R. Walker
  • J. A. Slack
Immunosuppression and Inflammation

Abstract

The effects of aspirin, salicylic acid and gentisic acid on the paw swellings in the arachidonic acid-potentiated and in the conventional carrageenan-induced oedema tests as well as on the content of prostaglandin-like activity and leucocyte migration in the exudate of inert implanted sponges in the rat have been studied. It is concluded that aspirin exerts two separate inhibitory effects on prostaglandin formation in vivo, a rapid action of the intact molecule on easily accessible tissues and a later action due to its metabolic conversion to salicylic acid. Salicylic acid inhibits prostaglandin biosynthesis in vivo as the salicylate ion itself and there is no formation of a subsequent ‘active’ metabolite.

Keywords

Aspirin Prostaglandin Salicylic Acid Salicylate Rapid Action 

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References

  1. [1]
    R.J. Gryglewski,Screening and Assessment of the Potency of Anti-inflammatory Drugs in vitro, in:Anti-Inflammatory Drugs (Eds. J.R. Vane and S.H. Ferreira; Springer-Verlag, Berlin, 1979), pp. 3–43.Google Scholar
  2. [2]
    T.Y. Shen,Prostaglandin Synthetase Inhibitors, in:Prostaglandin and Thromboxanes (Eds. F. Berti, B. Samuelsson and G.P. Velo; Plenum Press, N.Y., 1977), pp. 111–136.Google Scholar
  3. [3]
    A.L. Willis, R. Davison, P.W. Ramwell, W.D. Brocklehurst andB. Smith,Release and Actions of Prostaglandins in Inflammation and Fever: Inhibition by Anti-Inflammatory and Antipyretic Drugs, in:Prostaglandins in Cellular Biology (Eds. P.W. Ramwell and B.B. Pharris; Plenum Press, N.Y., 1972), pp. 227–259.Google Scholar
  4. [4]
    G.A. Higgs, E.A. Harvey, S.H. Ferreira andJ.R. Vane,The Effects of Anti-Inflammatory Drugs on the Production of Prostaglandins in vivo, in:Advances in Prostaglandin and Thromboxane Research, vol. 1 (Eds. B. Samuelsson and R. Paoletti; Raven Press, N.Y., 1976), pp. 105–110.Google Scholar
  5. [5]
    R.J. Flower andJ.R. Vane,Some Pharmacologic and Biochemical Aspects of Prostaglandin Biosynthesis and its Inhibition, in:Prostaglandin Synthetase Inhibitors (Eds. H.J. Robinson and J.R. Vane; Raven Press, N.Y., 1974), pp. 9–18.Google Scholar
  6. [6]
    E. Quilley andM.J.H. Smith,The Application of Paper Partition Chromatography to the Study of the Metabolism of Salicylate in the Rat, J. Pharm. Pharmac.4, 624–630 (1952).Google Scholar
  7. [7]
    M.J.H. Smith,Aspirin and Prostaglandins, Some Recent Developments, Agents and Actions8, 427–429 (1978).PubMedGoogle Scholar
  8. [8]
    M.J.H. Smith, A.W. Ford-Hutchinson andP.C. Elliott,Prostaglandins and the Anti-Inflammatory Activities of Aspirin and Sodium Salicylate, J. Pharm. Pharmac.27, 473–478 (1975).Google Scholar
  9. [9]
    J.R. Walker, M.J.H. Smith andA.W. Ford-Hutchinson,Anti-Inflammatory Drugs, Prostaglandins and Leucocyte Migration, Agents and Actions6, 602–606 (1976).PubMedGoogle Scholar
  10. [10]
    S.H. Ferreira andJ.R. Vane,Mode of Action of Anti-Inflammatory Agents which are Prostaglandin Synthetase Inhibitors, in:Anti-Inflammatory Drugs (Eds. J.R. Vane and S.H. Ferreira; Springer-Verlag, Berlin, 1979), p. 373.Google Scholar
  11. [11]
    J.A. Sturman andM.J.H. Smith,The Binding of Salicylate to Plasma Proteins in Different Species, J. Pharm. Pharmac.19, 621–623 (1967).Google Scholar
  12. [12]
    N.S. Doherty, M. Aattila andP.B. Dean,Penetration of Naproxen and Salicylate into Inflammatory Exudates in the Rat, Ann. Rheum. Dis.36, 244–248 (1977).PubMedGoogle Scholar
  13. [13]
    E.L. Tolman andR. Patridge,Multiple Sites of Interaction between Prostaglandins and Non-Steroidal Anti-Inflammatory Agents, Prostaglandins9, 349–359 (1975).PubMedGoogle Scholar
  14. [14]
    B. Fjalland,Inhibition by Non-Steroidal Anti-Inflammatory Agents of the Release of Rabbit Aorta Contracting Substance and Prostaglandins from Chopped Guinea Pig Lungs, J. Pharm. Pharmac.26, 448–451 (1974).Google Scholar
  15. [15]
    J.R. Vane,Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs, Nature (New Biol.)231, 232–235 (1971).Google Scholar
  16. [16]
    B.B. Vargaftig,Salicylic Acid Fails to Inhibit Generation of Thromboxane A 2 Activity after in vivo Administration to the Rat, J. Pharm. Pharmac.30, 101–104 (1978).Google Scholar
  17. [17]
    A.W. Ford-Hutchinson, J.R. Walker, N.S. Connor andM.J.H. Smith,Prostaglandins and Leucocyte Migration in Inflammatory Reactions, Agents and Actions7, 469–472 (1977).PubMedGoogle Scholar
  18. [18]
    J.R. Vane,The Mode of Action of Aspirin-like Drugs, Agents and Actions8, 430–431 (1978).PubMedGoogle Scholar
  19. [19]
    M.J.H. Smith andP.D. Dawkins,Salicylate and Enzymes, J. Pharm. Pharmac.23, 729–744 (1971).Google Scholar

Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • M. J. H. Smith
    • 1
  • A. W. Ford-Hutchinson
    • 1
  • J. R. Walker
    • 1
  • J. A. Slack
    • 1
  1. 1.Biochemical Pharmacology Research Unit, Department of Chemical PathologyKing's College Hospital Medical SchoolLondon

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