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Suppressor effects of histamine on SK/SD delayed hypersensitivity reactions in man and on E-rosette-forming cells

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Abstract

The effects of histamine on delayed hypersensitivity cutaneous reactions and on the formation of E-rosettes has been evaluated.

In vivo, concentrations of 10−3.6 M of histamine HCl significantly suppresses the cell-mediated reaction to antigen SK/SD at 24 and at 48 h.

In vitro, amine significantly inhibits the formation of E-rosettes in normal subjects. The inhibitory effect is significant at concentrations of 10−4 M for an incubation period at 37°C of 2 h with lymphocytes.

The suppressor effect of histamine in vivo may be mediated by an histamine-induced suppressor factor, while the one in vitro by an increase of intracellular cAMP.

No anti-H1 and anti-H2 drugs have been employed but the effects of histamine probably depend on H2-receptors.

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Authors and Affiliations

  1. Istituto di Clinica Medica, Cattedra di Reumatologia, Università degli Studi di Parma, Parma, Italia

    U. Ambanelli, G. F. Ferraccioli & P. Manganelli

  2. Istituto di Chimica Farmaceutica e Tossicologica, Università degli Studi di Parma, Parma, Italia

    G. L. Vaona

Authors
  1. U. Ambanelli
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  2. G. F. Ferraccioli
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  3. P. Manganelli
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  4. G. L. Vaona
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Ambanelli, U., Ferraccioli, G.F., Manganelli, P. et al. Suppressor effects of histamine on SK/SD delayed hypersensitivity reactions in man and on E-rosette-forming cells. Agents and Actions 9, 474–478 (1979). https://doi.org/10.1007/BF01968113

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  • DOI: https://doi.org/10.1007/BF01968113

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