Agents and Actions

, Volume 10, Issue 5, pp 422–426 | Cite as

Binding of [3H]cimetidine to rat brain tissue

  • Ian R. Smith
  • Mark T. Cleverley
  • C. Robin Ganellin
  • Kathleen M. Metters
Histamine and Kinins


Binding of [3H]cimetidine to rat brain tissue was investigated, and a saturable binding with dissociation constant 0.22±0.05 μM found. This binding is inhibited by a range of imidazole-derived histamine H2-receptor antagonists, but not by a number of non-imidazole H2-receptor antagonists. It is concluded that the [3H]cimetidine binding site in rat brain tissue that is labelled in these experiments is not the histamine H2-receptor.


Binding Site Histamine Brain Tissue Cimetidine Dissociation Constant 
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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • Ian R. Smith
    • 1
  • Mark T. Cleverley
    • 1
  • C. Robin Ganellin
    • 1
  • Kathleen M. Metters
    • 1
  1. 1.Research InstituteSmith Kline and French Research Ltd.Welwyn Garden CityUK

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