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Comparative study of azithromycin and amoxicillin/clavulanic acid in the treatment of lower respiratory tract infections

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Abstract

Forty-eight patients with acute bronchitis and four with pneumonia were randomly assigned to receive five doses (500 mg on day 1, plus 250 mg/day on days 2–5) of azithromycin; 54 patients with acute bronchitis and four with pneumonia were assigned 30 doses (625 mg every eight hours for ten days) of amoxicillin/clavulanic acid (CA). The two regimens were equally effective, with clinical improvement or cure in 92 % and 87 % of patients respectively, bacteriological cure in 89 % and 86 %, with 91 % and 89 % of pathogens eliminated. Minor side effects occurred in 6 % and 12 % of patients in the two groups, respectively. No major abnormalities in laboratory safety parameters were seen in either group.

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References

  1. Bright GM, Nagel AA, Bordner J, Desai KA, Dibring JN, Nowakowska J, Vincent L, Watrous RM, Sciavolino FC: Synthesis, in vitro and in vivo activity of novel 9-deoxo-9a-aza-9a homoerythromycin A derivatives: a new class of macrolides, the azalides. Journal of Antibiotics 1988, 41: 1029–1047.

    PubMed  Google Scholar 

  2. Retsema J, Girard A, Schelkly W, Manousos M, Anderson M, Bright G, Borovoy R, Brennan L, Mason R: Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms. Antimicrobial Agents and Chemotherapy 1987, 31: 1939–1947.

    PubMed  Google Scholar 

  3. Girard AE, Girard D, English AR, Gootz TD, Cimochowski CR, Faiella JA, Haskell SL, Retsema JA: Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution. Antimicrobial Agents and Chemotherapy 1987, 31: 1948–1954.

    PubMed  Google Scholar 

  4. Foulds G, Shepard RM, Johnson RB: The pharmacokinetics of azithromycin in human serum and tissues. Journal of Antimicrobial Chemotherapy 1990, 25, Supplement A: 73–82.

    Google Scholar 

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Authors and Affiliations

  1. Service de Pneumologie, Centre Hospitalier Regional et Universitaire, 5 rue Hoche, 30006, Nimes, France

    P. Balmes

  2. Centre Hospitalier Spécialisé, 50170, Pontorson, France

    G. Clerc

  3. Service de Maladies Infectieuses, Hôpital Pasteur, 75015, Paris, France

    B. Dupont

  4. Service de Médicine Interne, Centre Hospitalier, 51005, Chalons sur Marne, France

    C. Labram

  5. Service de Pneumologie et Réanimation, Hôpital Beaujon, 92110, Clichy, France

    R. Pariente

  6. Service de Pneumologie, Centre Hospitalier, 13616, Aixen-Provence, France

    R. Poirier

Authors
  1. P. Balmes
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  2. G. Clerc
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  3. B. Dupont
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  4. C. Labram
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  5. R. Pariente
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  6. R. Poirier
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Balmes, P., Clerc, G., Dupont, B. et al. Comparative study of azithromycin and amoxicillin/clavulanic acid in the treatment of lower respiratory tract infections. Eur. J. Clin. Microbiol. Infect. Dis. 10, 437–439 (1991). https://doi.org/10.1007/BF01968024

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  • DOI: https://doi.org/10.1007/BF01968024

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