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A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors

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Summary

The phosphodiesterase inhibitors papaverine, theophylline and 3-isobutyl-1-methylxanthine (IBMX) reveal a negative inotropic effect of acetylcholine in cat ventricular heart muscle. This effect is unrelated to β-adrenoceptor stimulation and possibly mediated by the accumulation of cyclic GMP.

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Author notes

  1. X. Zong (Visiting scient)

    Present address: Department of Pharmacology, Medical School of Wuhan, Wuhan, People's Republic of China

Authors and Affiliations

  1. Department of Pharmacology, University of Mainz, D-6500, Mainz, Federal Republic of Germany

    H. Nawrath, P. Gruschwitz & X. Zong (Visiting scient)

Authors
  1. H. Nawrath
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  2. P. Gruschwitz
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  3. X. Zong
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Additional information

I thank Mrs Petra Lauck for help. This work was supported by the Deutsche Forschungsgemeinschaft.

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Nawrath, H., Gruschwitz, P. & Zong, X. A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors. Experientia 37, 755–756 (1981). https://doi.org/10.1007/BF01967963

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  • DOI: https://doi.org/10.1007/BF01967963

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