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Pharmaceutisch Weekblad

, Volume 12, Issue 6, pp 275–279 | Cite as

Pharmacokinetics of cefuroxime in pregnant patients with preterm premature rupture of the membranes

  • F. J. M. E. Roumen
  • P. X. J. M. Bouckaert
  • H. M. H. G. Cremers
  • T. B. Vree
Antibiotics in Gynaecology and Obstetrics

Abstract

To 6 pregnant patients with preterm premature rupture of the membranes, cefuroxime prophylaxis was given 1,500 mg three times daily intravenously. Cefuroxime concentrations were assayed in maternal plasma and amniotic fluid during pregnancy and in umbilical cord blood, placenta, and membranes after delivery. Our results showed a high rate of transplacental transfer of cefuroxime. Bactericidal levels could be demonstrated in maternal plasma, and in amniotic fluid leaking from the vagina. Therapeutically active levels were present in the newborns. The absorption of cefuroxime by the foetal membranes was high. Although the neonatal morbidity in this high-risk population was low, the data are still too preliminary to advise the routine prophylactic use of cefuroxime to pregnant patients with preterm premature rupture of the membranes.

Keywords

Amniotic fluid Antibiotics Cefuroxime Membranes Pharmacokinetics Pregnancy Premature Rupture, spontaneous 

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References

  1. 1.
    Gibbs RS, Blanco JD. Premature rupture of the membranes. Obstet Gynecol 1982;60:671–9.PubMedGoogle Scholar
  2. 2.
    Monif GRG, Hume R, Goodlin RC. Neonatal considerations in the management of premature rupture of the fetal membranes. Obstet Gynecol Rev 1986;41:531–7.Google Scholar
  3. 3.
    Ohlsson A. Treatments of preterm premature rupture of the membranes: a meta-analysis. Am J Obstet Gynecol 1989;160:890–906.PubMedGoogle Scholar
  4. 4.
    Garite TJ, Freeman RK. Chorioamnionitis in the preterm gestation. Obstet Gynecol 1982;59:539–45.PubMedGoogle Scholar
  5. 5.
    Fayez JA, Hasan AA, Jonas HS, Miller GL. Management of premature rupture of the membranes. Obstet Gynecol 1978;52:17–21.PubMedGoogle Scholar
  6. 6.
    Toth M, Witkin SS, Ledger W, Thaler H. The role of infection in the etiology of preterm birth. Obstet Gynecol 1988;71:723–6.PubMedGoogle Scholar
  7. 7.
    Schoonmaker JN, Lawellin DW, Lunt B, McGregor JA. Bacteria and inflammatory cells reduce chorioamniotic membrane integrity and tensile strength. Obstet Gynecol 1989;74:590–6.PubMedGoogle Scholar
  8. 8.
    Schutte MF, Treffers PE, Soepatmi S. Voortijdig gebroken vliezen [Premature rupture of the membranes]. Ned Tijdschr Geneeskd 1981;125:81–5.PubMedGoogle Scholar
  9. 9.
    Lebherz TB, Hellman LP, Madding R, Anctil A, Arje SL. Double-blind study of premature rupture of the membranes. Am J Obstet Gynecol 1963;87:218–25.PubMedGoogle Scholar
  10. 10.
    Miller JM, Brazy JE, Gall SA, Crenshaw MC, Jelovsek FR. Premature rupture of the membranes. Maternal and neonatal infectious morbidity related to betamethasone and antibiotic therapy. J Reprod Med 1980;25:173–7.PubMedGoogle Scholar
  11. 11.
    Amon E, Lewis SV, Sibai BM, Villar MA, Arheart KL. Ampicillin prophylaxis in preterm premature rupture of the membranes: a prospective randomized study. Am J Obstet Gynecol 1988;159:539–43.PubMedGoogle Scholar
  12. 12.
    Craft I, Mullinger BM, Kennedy MRK. Placental transfer of cefuroxime. Br J Obstet Gynaecol 1981;88:141–5.PubMedGoogle Scholar
  13. 13.
    Bousfield P, Browning AK, Mullinger BM, Elstein M. Cefuroxime: potential use in pregnant women at term. Br J Obstet Gynaecol 1981;88:146–9.PubMedGoogle Scholar
  14. 14.
    Bergogne-Berezin E, Pierre J, Rouvillois JL, Dumez Y. Placental transfer of cefuroxime in late pregnancy. Drugs Exp Clin Res 1981;7:465–9.Google Scholar
  15. 15.
    Coppi G, Berti MA, Chehade A, Franchi I, Magro B. A study of the transplacental transfer of cefuroxime in humans. Curr Ther Res 1982;32:712–6.Google Scholar
  16. 16.
    Philipson A, Stiernstedt G. Pharmacokinetics of cefuroxime in pregnancy. Am J Obstet Gynecol 1982;142:823–8.PubMedGoogle Scholar
  17. 17.
    Lecaillon JB, Rouan MC, Souppart C, Febvre N, Juge F. Determination of cefsulodin, cefotiam, cephalexin, cefotaxime, desacetyl-cefotaxime, cefuroxime and cefroxadin in plasma and urine by high-performance liquid chromatography. J Chromatogr 1982;228:257–67.PubMedGoogle Scholar
  18. 18.
    Minkhoff HL, Schwarz RH. The rising cesarean section rate: can it safely be reversed? Obstet Gynecol 1980;56:135–43.PubMedGoogle Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • F. J. M. E. Roumen
    • 1
  • P. X. J. M. Bouckaert
    • 1
  • H. M. H. G. Cremers
    • 2
  • T. B. Vree
    • 3
  1. 1.Department of Obstetrics and GynaecologySt. Elisabeth ClinicPB Heerlenthe Netherlands
  2. 2.Department of Clinical Pharmacy and ToxicologyDe Wever HospitalCX Heerlenthe Netherlands
  3. 3.Department of Clinical PharmacyUniversity Hospital NijmegenHB Nijmegenthe Netherlands

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