Pharmacokinetics of cefuroxime in pregnant patients with preterm premature rupture of the membranes
- 35 Downloads
To 6 pregnant patients with preterm premature rupture of the membranes, cefuroxime prophylaxis was given 1,500 mg three times daily intravenously. Cefuroxime concentrations were assayed in maternal plasma and amniotic fluid during pregnancy and in umbilical cord blood, placenta, and membranes after delivery. Our results showed a high rate of transplacental transfer of cefuroxime. Bactericidal levels could be demonstrated in maternal plasma, and in amniotic fluid leaking from the vagina. Therapeutically active levels were present in the newborns. The absorption of cefuroxime by the foetal membranes was high. Although the neonatal morbidity in this high-risk population was low, the data are still too preliminary to advise the routine prophylactic use of cefuroxime to pregnant patients with preterm premature rupture of the membranes.
KeywordsAmniotic fluid Antibiotics Cefuroxime Membranes Pharmacokinetics Pregnancy Premature Rupture, spontaneous
Unable to display preview. Download preview PDF.
- 2.Monif GRG, Hume R, Goodlin RC. Neonatal considerations in the management of premature rupture of the fetal membranes. Obstet Gynecol Rev 1986;41:531–7.Google Scholar
- 14.Bergogne-Berezin E, Pierre J, Rouvillois JL, Dumez Y. Placental transfer of cefuroxime in late pregnancy. Drugs Exp Clin Res 1981;7:465–9.Google Scholar
- 15.Coppi G, Berti MA, Chehade A, Franchi I, Magro B. A study of the transplacental transfer of cefuroxime in humans. Curr Ther Res 1982;32:712–6.Google Scholar