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Widespread occurrence of multiple drug-resistantSalmonella typhi in India

  • E. J. Threlfall
  • L. R. Ward
  • B. Rowe
  • S. Raghupathi
  • V. Chandrasekaran
  • J. Vandepitte
  • P. Lemmens
Note

Abstract

Sixteen multiple drug resistant strains ofSalmonella typhi belonging to Vi-phage types E1 (14) and O (2) and isolated in Southeast India in 1991 were characterized. All strains were resistant to chloramphenicol and the majority to trimethoprim and ampicillin. In all strains these resistances were encoded by plasmids of the H1 incompatibility group with molecular weights ranging from 110 to 120 megadaltons. Physicians in European countries should be aware that treatment may fail if patients with typhoid fever who have recently returned from the Indian sub-continent are given first-line treatment with chloramphenicol, trimethoprim or ampicillin. With the possible exception of young children, ciprofloxacin is currently the best choice for treatment of such patients.

Keywords

Molecular Weight Internal Medicine Young Child European Country Ampicillin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1992

Authors and Affiliations

  • E. J. Threlfall
    • 1
  • L. R. Ward
    • 1
  • B. Rowe
    • 1
  • S. Raghupathi
    • 2
  • V. Chandrasekaran
    • 2
  • J. Vandepitte
    • 3
  • P. Lemmens
    • 3
  1. 1.Division of Enteric Pathogens, Central Public Health LaboratoryWHO Collaborating Centre for Phage Typing and Resistance in EnterobacteriaLondonUK
  2. 2.St. Joseph HospitalDindigulIndia
  3. 3.Department of MicrobiologySt-Rafaël University HospitalLeuvenBelgium

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