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, Volume 11, Issue 3, pp 296–305 | Cite as

Metal binding by pharmaceuticals. Part 1. Copper(II) and zinc(II) interactions following ethambutol administration

  • Alun Cole
  • Peter M. May
  • David R. Williams
Bioinorganic Interactions

Abstract

Formation constants for copper(II) and zinc(II) complexes of dextro-2,2′-(ethylenediimino)-di-1-butanol (ethambutol) and its metabolic oxidation product, 2,2′-(ethylenediimino)-dibutyric acid (EDBA) have been measured potentiometrically at 37°C, I=0.15 mol dm−3 [NaCl]. The constants are used in computer models to assess the extent of the formation of these complexes in vivo. These simulations indicate that whereas ethambutol forms metal complexes only to a limited extent in vivo, EDBA competes effectively under physiological conditions for copper(II) and zinc(II). This study suggests that zinc(II) binding by EDBA may account for a number of side effects of ethambutol treatment.

Keywords

Copper Zinc Physiological Condition Computer Model Metal Complex 

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Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • Alun Cole
    • 1
  • Peter M. May
    • 1
  • David R. Williams
    • 1
  1. 1.Department of ChemistryUniversity of Wales Institute of Science and TechnologyCardiffWales UK

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