Abstract
Ranitidine hydrochloride solution was given rectally to six healthy volunteers by means of an osmotic pump (Osmet®) at a zero-order rate for 8 h. Quite constant steady-state drug concentrations were achieved in the range of 64–123 ng/ml plasma (meanC ss: 100.6 ng/ml). The mean absorption time was 0.45 h (range 0–1.02 h), indicating that absorption was not always instantaneous. It is concluded that the Osmet® system together with the rectal route offer the possibility for achieving steady-state concentrations of ranitidine, enabling the determination of pharmacodynamic effects. In addition, the rectal route can be considered as an alternative to oral and intravenous administration.
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de Bree, H., de Boer, A.C. Kinetics of rate controlled rectally administered ranitidine to male volunteers. Pharmaceutisch Weekblad Scientific Edition 9, 179–182 (1987). https://doi.org/10.1007/BF01967538
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DOI: https://doi.org/10.1007/BF01967538