Skip to main content
SpringerLink
Log in

Fungicidal activity of cilofungin (LY121019) alone and in combination with anticapsin or other antifungal agents

  • New Antimicrobial Agents
  • Published:
European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

Cilofungin (LY121019) was shown to have potent fungicidal activity against clinical isolates ofCandida albicans andCandida tropicalis but notCandida parapsilosis. Fungicidal activity was evident against both replicating and non-replicatingCandida albicans and was progressive over the first 12 h of incubation. The combination of cilofungin (LY121019) with anticapsin but not with amphotericin B, ketoconazole or 5-fluorocytosine resulted in synergistic fungicidal activity. This compound warrants further investigation of its safety and efficacy in the treatment ofCandida infections.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Horn, R., Wong, B., Kiehn, T. E., Armstrong, D.: Fungemia in a cancer hospital: changing frequency, earlier onset, and results of therapy. Reviews of Infectious Diseases 1985, 7: 646–655.

    PubMed  Google Scholar 

  2. Medoff, G., Kobayashi, G. S.: Strategies in the treatment of systemic fungal infections. New England Journal of Medicine 1980, 302: 145–155.

    PubMed  Google Scholar 

  3. Gordee, R. S., Zeckner, D. J., Ellis, L. F., Thakker, A. L., Howard, L. C.: In vitro and in vivo anti-Candida activity and toxicology of LY121019. Journal of Antibiotics 1984, 37: 1054–1065.

    PubMed  Google Scholar 

  4. Spitzer, E. D., Travis, S. J., Kobayashi, G. S.: Comparative in vitro activity of LY121019 and amphotericin B against clinical isolates ofCandida species. European Journal of Clinical Microbiology and Infectious Diseases 1988, 7: 80–81.

    Article  Google Scholar 

  5. Hobbs, M., Perfect, J., Durack, D.: Evaluation of in vitro antifungal activity of LY121019. European Journal of Clinical Microbiology and Infectious Diseases 1988, 7: 77–80.

    Article  Google Scholar 

  6. Milewski, S., Chmara, H., Borowski, E.: Anticapsin: an active site directed inhibitor of glucosamine-6-phosphate synthetase fromCandida albicans. Drugs in Experimental and Clinical Research 1986, XII: 577–583.

    Google Scholar 

  7. Milewski, S., Chmara, H., Borowski, E.: Antibiotic tetaine — a selective inhibitor of chitin and manoprotein biosynthesis inCandida albicans. Archives of Microbiology 1986, 145: 234–240.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Veterans Administration Medical Center, 52240, Iowa City, Iowa, USA

    M. Pfaller

  2. Department of Pathology, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA

    M. Pfaller, T. Gerarden & M. Yu

  3. Department of Internal Medicine, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA

    R. Wenzel

  4. Lilly Research Laboratories, Eli Lilly and Company, 46206, Indianapolis, Indiana, USA

    R. Gordee

Authors
  1. M. Pfaller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Gordee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Gerarden
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Wenzel
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pfaller, M., Gordee, R., Gerarden, T. et al. Fungicidal activity of cilofungin (LY121019) alone and in combination with anticapsin or other antifungal agents. Eur. J. Clin. Microbiol. Infect. Dis. 8, 564–567 (1989). https://doi.org/10.1007/BF01967483

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01967483

Keywords

Search

Navigation