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Treatment of chronic experimentalStaphylococcus aureus osteomyelitis with LY146032 and vancomycin

  • New Antimicrobial Agents
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Abstract

LY146032 and vancomycin were compared as therapeutic agents in the treatment of chronicStaphylococcus aureus osteomyelitis in the rat. Quantitative cultures disclosed that one of 16, none of 16, and two of 17 tibiae were sterile from the control, LY146032, and vancomycin groups, respectively. From positive cultures, geometric mean staphylococcal CFU per gram of bone were as follows: control, 5.13±1.58; LY146032, 5.36±0.43 (p=0.57); and vancomycin, 4.33±1.73 (p=0.078). Mean gross pathology was decreased significantly in both treatment groups. LY146032 was no more effective than vancomycin in reducing bacterial counts.

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Authors and Affiliations

  1. Mercer School of Medicine, 1500 Coleman Avenue, 31298, Macon, Georgia, USA

    Q. N. Luu

  2. Veterans Administration Medical Center, Infectious Disease Laboratory and the Medical College of Georgia, 30910, Augusta, Georgia, USA

    Q. N. Luu, T. B. Buxton, D. R. Nelson & J. P. Rissing

  3. Dublin Internal Medicine, Inc., 606 Academy, 31021, Dublin, Georgia, USA

    D. R. Nelson

Authors
  1. Q. N. Luu
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  2. T. B. Buxton
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  3. D. R. Nelson
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  4. J. P. Rissing
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Luu, Q.N., Buxton, T.B., Nelson, D.R. et al. Treatment of chronic experimentalStaphylococcus aureus osteomyelitis with LY146032 and vancomycin. Eur. J. Clin. Microbiol. Infect. Dis. 8, 562–563 (1989). https://doi.org/10.1007/BF01967482

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  • DOI: https://doi.org/10.1007/BF01967482

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