Abstract
Twenty-six patients undergoing elective gastro-intestinal surgery received a 1 g intravenous dose of cefpirome before operation. Serum and peritoneal fluid samples, obtained 0.5–7.6 h following administration, were assayed for cefpirome by a microbiological assay. The serum half-life of cefpirome was 2.1 h. The mean concentration of cefpirome in peritoneal fluid 0–2 h after administration was 44.4 µg/ml. The half-life of cefpirome in peritoneal fluid was 2 h, with mean concentrations of >10 µg/ml measured 6 h after administration. The mean percentage of intraperitoneal penetration of cefpirome over the study period was 97.7 %. The therapeutic implications are discussed.
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References
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Kavi, J., Ashby, J.P., Wise, R. et al. Intraperitoneal penetration of cefpirome. Eur. J. Clin. Microbiol. Infect. Dis. 8, 556–558 (1989). https://doi.org/10.1007/BF01967480
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DOI: https://doi.org/10.1007/BF01967480