Abstract
The sensitivity of histamine H2 receptors of the gastric mucosa after one month treatment with ranitidine, administered daily (5 mg/kg i.m.), was checked in 5 conscious cats provided with gastric fistula. Basal acid secretion as well as the acid response to the H2 agonist dimaprit (60 μg/kg/hr) were studied before and at different periods after cessation of ranitidine treatment (1, 3, 7 and 14 days). Control experiments were carried out in 5 gastric fistula cats which received daily physiological saline for one month. Basal acid secretion in treated animals increased significantly (P<0.05) from 0.04±0.002 to 0.24±0.05 mEq H+/10 min. Also the response to dimaprit increased significantly (p<0.05) from 0.49±0.08 to 0.86±0.12 mEq H+/10 min. Seven days after cessation of treatment, both basal and stimulated secretion returned to pretreatment levels. In control cats no significant difference was noticed in basal and stimulated secretion at the beginning and at the end of the study.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. D. Hollenberg,Membrane receptors and hormone action I. Trends. Pharmac. Sci.2, 320–323 (1981).
G. L. Stiles, M. G. Caron and R. J. Lefkowitz,β-adrenergic receptors: biochemical mechanisms of physiological regulation. Phys. Rev.64, 661–743 (1984).
E. Aadland and A. Berstad,Parietal and chief cell sensitivity to histamine and pentagastrin stimuation before and after cimetidine treatment in healthy subjects. Sc. J. Gastroenterol.14, 933–938 (1979).
R. Mohammed, R. J. Holden, J. B. Hearns, B. M. McKibben, K. D. Buchanan, G. P. Crean,Effects of eight week's continuous treatment with oral ranitidine and cimetidine on gastric acid secretion, pepsin secretion, and fasting serum gastrin. Gut24, 61–66 (1983).
K. Frislid, E. Aadland and A. Berstad,Augmented postprandial gastric acid secretion due to exposure to ranitidine in healthy subjects. Sc. J. Gastroenterol21, 119–122 (1986).
D. B. Jones, C. W. Howden, D. W. Burget, C. Silletti and R. H. Hunt,Alteration of H 2 -receptor sensitivity during maintenance rantidine treatment. Gut27, A1255 (1986).
S. Emas, K. G. Swan and E. D. Jacobson,Methods of studying gastric secretion. In:Handbook of Physiology. (Ed. C. F. Code) pp. 743–758. American Physiological Society, Washington 1967.
W. Lorenz, A. Doenicke and W. Dietz,Release of histamine by H 2 -receptor antagonists. LancetII, 1098 (1987).
H. Boudoulas, R. P. Lewis, R. E. Kates and G. Dalamangas,Hypersensitivity to adrenergic stimulation after propranolol withdrawal in normal subjects. Ann. Intern. Med.87, 433–436 (1977).
R. R. Miller, H. G. Olson, E. A. Amsterdam and D. T. Mason,Propranolol withdrawal rebound phenomenon exacerbation of coronary events after abrupt cessations of antianginal therapy. N. Engl. J. Med.293, 416–418 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Coruzzi, G., Bertaccini, G. Increased parietal cell sensitivity after chronic treatment with ranitidine in the conscious cat. Agents and Actions 28, 215–217 (1989). https://doi.org/10.1007/BF01967404
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01967404