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In vitro antimicrobial activity of imipenem in combination with vancomycin or teicoplanin againstStaphylococcus aureus andStaphylococcus epidermidis

  • J. G. Barr
  • E. T. M. Smyth
  • G. M. Hogg
Article

Abstract

The interaction between imipenem and two glycopeptides against staphylococci was examined for potential synergy. Imipenem in combination with vancomycin or teicoplanin exerted a synergistic or additive effect against a majority ofStaphylococcus aureus andStaphylococcus epidermidis isolates tested by the checkerboard method. Synergistic inhibitory effects were frequently accompanied by synergistic bactericidal effects. For a proportion of bacterial isolates of both species, the demonstration of synergy by the checkerboard method was confirmed by time-kill studies using antibiotic combinations at the MICs or at achievable serum antibiotic levels. Only with a single isolate ofStaphylococcus epidermidis was antagonism with either antibiotic combination recorded.

Keywords

Internal Medicine Antimicrobial Activity Vancomycin Bacterial Isolate Glycopeptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Sculier JP, Weerts D, Klastersky J: Causes of death in febrile granulocytopenic patients. European Journal of Cancer and Clinical Oncology 1984, 20: 55–60.Google Scholar
  2. 2.
    Richardson JF, Marples RR: changing resistance to antimicrobial drugs, and resistance typing in clinically significant strains ofStaphylococcus epidermidis. Journal of Medical Microbiology 1982, 15: 475–484.PubMedGoogle Scholar
  3. 3.
    Watanakunakorn C: In vitro induction of resistance in coagulase-negative staphylococci to vancomycin and teicoplanin. Journal of Antimicrobial Chemotherapy 1988, 22: 321–324.PubMedGoogle Scholar
  4. 4.
    Moore EP, Speller DCE: In vitro teicoplanin resistance in coagulase-negative staphylococci from patients with endocarditis and from a cardiac surgery unit. Journal of Antimicrobial Chemotherapy 1988, 21: 417–424.PubMedGoogle Scholar
  5. 5.
    Glupczynski Y, Lagast H, Van der Auwera P, Thys JP, Crokaert F, Yourassowsky E, Meunier-Carpentier F, Klaskersky J, Kaus JP, Serruys-Schoutens E, Legrand JC: Clinical evaluation of teicoplanin for therapy of severe infections caused by gram-positive bacteria. Antimicrobial Agents and Chemotherapy 1986, 29: 52–57.PubMedGoogle Scholar
  6. 6.
    Klastersky J, Glauser MP, Schimpff SC, Zinner SH, Gaya H: Prospective randomised comparison of three antibiotic regimens for empirical therapy of suspected bacteraemic infection in febrile granulocytopenic patients. Antimicrobial Agents and Chemotherapy 1986, 29: 263–270.PubMedGoogle Scholar
  7. 7.
    Roper BL, Gutschik E: In vitro activity of ciprofloxacin combined with either fusidic acid or rifampicin againstStaphylococcus aureus. Journal of Antimicrobial Chemotherapy 1989, 23: 347–352.PubMedGoogle Scholar
  8. 8.
    Baltch AL, Bassay C, Fanciullo G, Smith RP: In vitro antimicrobial activity of enoxacin in combination with eight other antibiotics againstPseudomonas aeruginosa, Enterobacteriaceae andStaphylococcus aureus. Journal of Antimicrobial Chemotherapy 1987, 19: 45–48.PubMedGoogle Scholar
  9. 9.
    Miles AA, Misra SS: The estimation of the bactericidal power of the blood. Journal of Hygiene 1938, 38: 732–748.Google Scholar
  10. 10.
    Proctor RA, Wick P, Hamill RJ, Horstmeier P, Gullings-Handley J, Weisensel M, Brand G: In vitro studies of combinations for multiply resistant coagulase-negative staphylococci. Journal of Antimicrobial Chemotherapy 1987, 20: 223–231.PubMedGoogle Scholar
  11. 11.
    Debbia E, Pesce A, Schito GC: In vitro interactions between teicoplanin and other antibiotics against enterococci and staphylococci. Journal of Hospital Infection 1986, 7, Supplement A: 73–77.PubMedGoogle Scholar
  12. 12.
    Watt B: Interaction of teicoplanin with other antimicrobial agents against gram-positive aerobes. Journal of Antimicrobial Chemotherapy 1989, 23: 657–658.PubMedGoogle Scholar
  13. 13.
    Bayer AS, Morrison JO: Disparity between time-kill and checkerboard methods for determination of in vitro bacterial interaction of vancomycin plus rifampicin versus methicillin-susceptibleStaphylococcus aureus. Antimicrobial Agents and Chemotherapy 1984, 26: 220–223.PubMedGoogle Scholar
  14. 14.
    Durack DT, Petersdorf RG: Chemotherapy of experimental staphylococcal endocarditis. I: Comparison of commonly recommended prophylactic regimens. Journal of Clinical Investigations 1973, 52: 592–598.Google Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1990

Authors and Affiliations

  • J. G. Barr
    • 1
  • E. T. M. Smyth
    • 1
  • G. M. Hogg
    • 1
  1. 1.Department of BacteriologyRoyal Victorial HospitalBelfastUK

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