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Mammalian histidine decarboxylase: Effect by protein kinase on mouse mastocytoma histidine decarboxylase

  • Histamine Metabolism
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Abstract

Mouse mastocytoma histidine decarboxylase is decreased in activity when, in crude preparations, incubated with a cAMP-dependent protein kinase. This effect was not seen with purified preparations of the histidine decarboxylase (specific activity 7–13 μmol·mg−1·h−1). Further, no incorporation of32P from AT32P during incubation of this enzyme with the protein kinase could be demonstrated. Therefore, if protein phosphorylation operates in the regulation of the histidine decarboxylase, factors removed during the purification must be involved.

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  1. Institute of Biochemistry, University of Uppsala, Biomedical Center, Box 576, S-751 23, Uppsala, Sweden

    Lena Hammar

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  1. Lena Hammar
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Hammar, L. Mammalian histidine decarboxylase: Effect by protein kinase on mouse mastocytoma histidine decarboxylase. Agents and Actions 13, 246–249 (1983). https://doi.org/10.1007/BF01967343

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