Agents and Actions

, Volume 13, Issue 2–3, pp 233–234 | Cite as

In vivo inhibition of phospholipaseA2 in rat lung by an β-adrenergic agonist

  • P. v. Wichert
  • W. Meyer
Histamine and Immunology


Phospholipase A2 is the key enzyme for the release of arachidonic acid derived mediators via cycloxygenase or lipoxygenase pathways in inflammation and immunological processes. Activity of microsomal phospholipase A2 in rat lung can be inhibited byin vivo application of the ß-adrenergic drug fenoterol both in control and diseased animals.


Arachidonic Acid Diseased Animal Fenoterol Lipoxygenase Pathway Immunological Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. [1]
    D.P. Wallach andV.J.R. Brown,Studies on the arachidonic acid cascade inhibition of phospholipase A 2 in vitro and in vivo by inhibitors, Biochem. Pharmac.30, 1315 (1981).CrossRefGoogle Scholar
  2. [2]
    R.J. Flower andG.J. Blackwell,Anti-inflammatory steroids induce biosynthesis of a phospholipase inhibitor which prevents prostaglandin generation, Nature, Lond.278, 456 (1979).Google Scholar
  3. [3]
    M.J. Oyarzun andJ.A. Clements,Control of lung surfactant by ventilation, adrenergic mediators, and prostaglandins in the rabbit, Am. Rev. resp. Dis.117, 879 (1978).PubMedGoogle Scholar
  4. [4]
    L.G. Dobbs andR.J. Mason,Pulmonary alveolar type II cells isolated from rats. J. clin. Invest.63, 378 (1979).PubMedGoogle Scholar
  5. [5]
    J.W. Rubin, G.H.A. Clowes Jr., M.F Macnocol andJ.W. Gawin,Impaired pulmonary surfactant synthesis in starvation and severe non-thoracic sepsis, Am. J. Surg.123, 461 (1972).CrossRefPubMedGoogle Scholar
  6. [6]
    P. v. Wichert, U. Wiegers, W. Stephan, A. Huck, P. Eckert andK. Riesner,Altered metabolism of phospholipids in the lung of rats with peritonitis, Res. exp. Med.172, 223 (1978).CrossRefGoogle Scholar
  7. [7]
    P. v. Wichert, M. Temmesfeld andW. Meyer,Influence of septic shock upon phosphatidylcholine remodelling mechanism in rat lung, Biochim. biophys. Acta664, 487 (1981).PubMedGoogle Scholar
  8. [8]
    R.H. Demling, M. Smith, R. Gunther, J.T. Flynn andM.H. Gee,Pulmonary injury and prostaglandin production during endotoxinemia in conscious sheep, Am. J. Physiol.240, H348 (1981).PubMedGoogle Scholar
  9. [9]
    R.B. Passi andF. Possmayer, Surfactant metabolism in acute pancreatitis. InClinical Importance of Surfactant Defects, p. 136 (Ed.P.V. Wichert). Karger Verlag, Basel, New York 1981.Google Scholar

Copyright information

© Birkhäuser Verlag 1983

Authors and Affiliations

  • P. v. Wichert
    • 1
  • W. Meyer
    • 1
  1. 1.Medizinische Poliklinik der Philipps-Universität MarburgMarburg/LahnFederal Republic of Germany

Personalised recommendations