Abstract
Somatostatin is a potent histamine secretagogue found not only in rat mast cells but also in human leukocyte preparations. In concentrations ≥5 μmol/l, somatostatin-14 induces histamine release, which correlates with the basophilic blood cell count, as shown in samples from allergic patients suffering from slight basophilia. Somatostatin-14 is twice as effective as somatostatin-28 on a molar basis, and acylating the tetradecapeptide withN-hydroxysuccinimidyl-p-hydroxy-phenyl-propionate decreases significantly the potency of histamine release.
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Diel, F., Bethge, N. & Opree, W. Histamine secretion in leukocyte incubates of patients with allergic hyperreactivity induced by somatostatin-14 and somatostatin-28. Agents and Actions 13, 216–218 (1983). https://doi.org/10.1007/BF01967335
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DOI: https://doi.org/10.1007/BF01967335