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Agents and Actions

, Volume 26, Issue 3–4, pp 386–390 | Cite as

The effect of tiaprofenic acid and indomethacin administration of human platelet function

  • M. A. Barradas
  • J. Y. Jeremy
  • D. P. Mikhailidis
  • P. Dandona
Platelets and Thrombosis

Abstract

The present study compares the effects of two non-steroidal anti-inflammatory drugs (NSAIDs) on platelet function. Tiaprofenic acid (300 mg twice daily) and indomethacin (25 mg thrice daily) were administered to healthy volunteers for 6 days. Platelet aggregation and thromboxane A2 (TXA2) release (assessed as TXB2, the stable, spontaneous breakdown product of TXA2) were assessed before the adminstration of NSAIDs; on day 6 (2–3 h after the last dose of NSAID); and on days 7 and 8 (24 h and 48 h after the last dose of NSAID). Both tiaprofenic acid and indomethacin significantly inhibited platelet aggregation and TXA2 release. The extent and duration of inhibition was similar for both drugs, and the inhibition tended to reverse within 24–48 h of cessation of medication. The time required for reversal of the inhbitiory effect of NSAIDs on platelets may be of relevance in patients who are bleeding (e.g. from gastric erosions caused by NSAIDs). Tiaprofenic acid in the present study and in previous work has not been shown to be a selective inhibitor of prostanoid synthesis, as was originally claimed.

Keywords

Healthy Volunteer Indomethacin Platelet Aggregation Selective Inhibitor Thromboxane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • M. A. Barradas
    • 1
  • J. Y. Jeremy
    • 1
  • D. P. Mikhailidis
    • 1
  • P. Dandona
    • 1
  1. 1.Metabolic Unit, Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of MedicineUniversity of LondonLondonUK

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