The effect of tiaprofenic acid and indomethacin administration of human platelet function
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The present study compares the effects of two non-steroidal anti-inflammatory drugs (NSAIDs) on platelet function. Tiaprofenic acid (300 mg twice daily) and indomethacin (25 mg thrice daily) were administered to healthy volunteers for 6 days. Platelet aggregation and thromboxane A2 (TXA2) release (assessed as TXB2, the stable, spontaneous breakdown product of TXA2) were assessed before the adminstration of NSAIDs; on day 6 (2–3 h after the last dose of NSAID); and on days 7 and 8 (24 h and 48 h after the last dose of NSAID). Both tiaprofenic acid and indomethacin significantly inhibited platelet aggregation and TXA2 release. The extent and duration of inhibition was similar for both drugs, and the inhibition tended to reverse within 24–48 h of cessation of medication. The time required for reversal of the inhbitiory effect of NSAIDs on platelets may be of relevance in patients who are bleeding (e.g. from gastric erosions caused by NSAIDs). Tiaprofenic acid in the present study and in previous work has not been shown to be a selective inhibitor of prostanoid synthesis, as was originally claimed.
KeywordsHealthy Volunteer Indomethacin Platelet Aggregation Selective Inhibitor Thromboxane
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- K. Schror, V. Neuhaus, B. Ahland, S. Sauerland, A. Kuhn, H. Darius and K. Bussman,Actions of tiaprofenic acid on vascular prostacyclin biosynthesis and thromboxane A 2 and 12-HPETE formation of human platelets in vitro and ex vivo. Rheumatology7, 88–98 (1982).Google Scholar
- A. Kuhn, S. Sauerland, K. Schiffer and K. Schror,The action of non-steroidal anti-inflammatory agents on platelet aggregation and vessel tone in relation to inhibition of PGI 2 and thromboxane release. Arzneim. Forsch.30, 1538–1542 (1980).Google Scholar
- A. Del Favero,Antipyretic analgesics. InSide Effects of Drugs Annual, vol.12, (Eds. M. N. G. Dukes and L. Beeley) pp. 79–100, Amsterdam, Elsevier 1988.Google Scholar
- C. Dyer,The penalties of issuing misleading advertisements. Br. Med. J.294, 426–427 (1987).Google Scholar
- S. J. Warrington, A. Halsey and L. O'Donnell,A comparison of gastrointestinal bleeding in healthy volunteers treated with tiaprofenic acid, aspirin or ibuprofen. Rheumatology7, 107–110 (1982).Google Scholar
- S. J. Warrington, M. Horton and I. B. Davies,High dose tiaprofenic acid, naproxen and aspirin: comparison of effects on gastrointestinal blood loss. Br. J. Clin. Pharmacol.18, 301P-302P (1984).Google Scholar
- C. S. M. Update,Non-steroidal anti-inflammatory drugs and serious gastrointestinal adverse reactions-2. Br. Med. J.292, 1190–1191 (1986).Google Scholar
- D. P. Mikhailidis, J. Y. Jeremy, M. A. Barradas, N. Green and P. Dandona,Effect of ethanol on vascular prostacyclin (prostaglandin I 2)synthesis, platelet aggregation and platelet thromboxane A 2 release. Br. Med. J.287, 1495–1498 (1983).Google Scholar
- D. P. Mikhailidis, R. A. Hutton, J. Y. Jeremy and P. Dandona,Cooling decreases efficiency of prostaglandin inhibitors of platelet aggregation. Microcirculation2, 413–423 (1983).Google Scholar