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In vitro comparison of cilofungin alone and in combination with other antifungal agents against clinical isolates ofCandida species

  • New Antimicrobial Agents
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Abstract

Cilofungin, a lipopeptide antifungal agent, was tested for in vitro activity alone and in combination with ketoconazole, itraconazole, flucytosine and amphotericin B against 102 clinical isolates ofCandida species. At 48 hours all isolates ofCandida albicans, Candida tropicalis, Candida paratropicalis andCandida glabrata were inhibited by ≤5 mcg/ml of cilofungin. In contrast, the MIC90 forCandida krusei was 10 mcg/ml and forCandida parapsilosis >40 mcg/ml. The interaction of combinations of cilofungin with amphotericin B, itraconazole, ketoconazole and flucytosine was additive or indifferent at 48 hours for 100 %, 88 %, 78 % and 70 % of allCandida species isolates, respectively. Overall, cilofungin demonstrated good activity in vitro against mostCandida species isolates.

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Authors and Affiliations

  1. Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, THT 229, University Station, 35294, Birmingham, Alabama, USA

    K. R. Smith, K. M. Lank, W. E. Dismukes & C. G. Cobbs

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  1. K. R. Smith
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  2. K. M. Lank
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  3. W. E. Dismukes
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  4. C. G. Cobbs
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Smith, K.R., Lank, K.M., Dismukes, W.E. et al. In vitro comparison of cilofungin alone and in combination with other antifungal agents against clinical isolates ofCandida species. Eur. J. Clin. Microbiol. Infect. Dis. 10, 588–592 (1991). https://doi.org/10.1007/BF01967280

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