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In vitro activity of cefpodoxime, a new oral cephalosporin, compared with that of nine other antimicrobial agents

  • New Antimicrobial Agents
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European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

The in vitro activity of the compound RU-51746, the sodium salt of cefpodoxime (which is administered orally as the ester cefpodoxime proxetil) was compared with that of other commonly used oral antibiotics against a selection of clinical isolates of common bacteria from patients with urinary tract, soft tissue and respiratory tract infections. RU-51746 was found to inhibit 90 % ofEnterobacteriaceae at <1 mg/l; pneumococci, pyogenic streptococci (Lancefield groups A, C and G) andStreptococcus agalactiae were almost all inhibited by concentrations of <0.06 mg/l;Haemophilus influenzae (including beta-lactamase producers) were inhibited by <1 mg/l; 90 % ofBranhamella catarrhalis were inhibited at <2 mg/l. Activity againstAcinetobacter spp. and staphylococci was variable and enterococci were all resistant.

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References

  1. Jones R, Barry A Antimicrobial activity and disc diffusion susceptibility testing of U-76, 235A (R-3746), the active metabolite of the new cephalosporin ester, U-76, 252 (CS-807). Antimicrobial Agents and Chemotherapy 1988, 32: 443–449.

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  2. King A, Warren C, Shannon K, Phillips I The in vitro antibacterial activity of ocfotaxime compared with that of cefuroxime and cefoxitin. Journal of Antimicrobial Chemotherapy 1980, 6: 479–494.

    PubMed  Google Scholar 

  3. Working Party of the British Society for Antimicrobial Chemotherapy Breakpoints in in vitro antibiotic sensitivity testing. Journal of Antimicrobial Chemotherapy 1988, 21: 701–710.

    Google Scholar 

  4. Chin NX, Neu H In vitro activity of an oral iminomethoxy aminothiazolyl cephalosporin, R-3746. Antimicrobial Agents and Chemotherapy 1988, 32: 671–677.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, United Medical and Dental Schools, St. Thomas' Hospital, Lambeth Palace Rd., SE1 7EH, London, UK

    M. Sheppard, A. King & I. Phillips

Authors
  1. M. Sheppard
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  2. A. King
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  3. I. Phillips
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Sheppard, M., King, A. & Phillips, I. In vitro activity of cefpodoxime, a new oral cephalosporin, compared with that of nine other antimicrobial agents. Eur. J. Clin. Microbiol. Infect. Dis. 10, 573–581 (1991). https://doi.org/10.1007/BF01967277

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  • DOI: https://doi.org/10.1007/BF01967277

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