Abstract
The killing kinetics of cefuroxime against 25Streptococcus pneumoniae isolates with penicillin MICs of <0.1, 0.1–1.0 and 2 mg/l were studied in an in vitro model simulating the serum concentration profile in healthy adults following a single intramuscular injection of 500 mg. Cefuroxime was bactericidal against the isolates with exquisite or slightly diminished susceptibility to penicillin (−4 and −3.9 log10 cfu/ml killing, respectively) during the 6 h incubation period. In contrast, there was only a 2.8 log10 cfu/ml reduction in the initial inoculum of six of the eight isolates resistant to penicillin (MIC 2 mg/l). The two remaining penicillin-resistant isolates (cefuroxime MIC 8 mg/l) only showed a 2 log10 cfu reduction in the initial inoculum.
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Bingen, E., Doit, C., Farinotti, R. et al. Killing kinetics of cefuroxime againstStreptococcus pneumoniae in an in vitro model simulating serum concentration profiles after intramuscular administration. Eur. J. Clin. Microbiol. Infect. Dis. 12, 297–299 (1993). https://doi.org/10.1007/BF01967263
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DOI: https://doi.org/10.1007/BF01967263