Agents and Actions

, Volume 23, Issue 1–2, pp 69–73 | Cite as

Flare up of joint inflammations induced by cloned helper T cells. Retention of the helper T cells

  • I. S. Klasen
  • R. M. T. Ladestein
  • W. B. van den Berg
  • R. Benner
Chondrocytes, Cartilage and Joint Damage


Joint inflammations were induced in mice by intra articular (ia) injection of cloned helper T cells specific for methylated bovine serum albumin (mBSA) together with mBSA. Local injection of mBSA several weeks after waning of a joint inflammation induced by cloned helper T cells caused a flare up reaction. This indicates that the helper T cells persisted in the joint after the primary inflammation. In the present paper we show that the helper T cells can also persist for some time in a knee joint in the absence of the specific antigen and/or an inflammatory reaction.


Methylated Albumin Bovine Serum Bovine Serum Albumin Serum Albumin 


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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • I. S. Klasen
    • 2
  • R. M. T. Ladestein
    • 2
  • W. B. van den Berg
    • 1
  • R. Benner
    • 2
  1. 1.Department of RheumatologyUniversity Hospital St. RadboudNijmegenThe Netherlands
  2. 2.Department of Cell Biology, Immunology and GeneticsErasmus UniversityRotterdamThe Netherlands

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