Advertisement

Agents and Actions

, Volume 23, Issue 1–2, pp 69–73 | Cite as

Flare up of joint inflammations induced by cloned helper T cells. Retention of the helper T cells

  • I. S. Klasen
  • R. M. T. Ladestein
  • W. B. van den Berg
  • R. Benner
Chondrocytes, Cartilage and Joint Damage

Abstract

Joint inflammations were induced in mice by intra articular (ia) injection of cloned helper T cells specific for methylated bovine serum albumin (mBSA) together with mBSA. Local injection of mBSA several weeks after waning of a joint inflammation induced by cloned helper T cells caused a flare up reaction. This indicates that the helper T cells persisted in the joint after the primary inflammation. In the present paper we show that the helper T cells can also persist for some time in a knee joint in the absence of the specific antigen and/or an inflammatory reaction.

Keywords

Methylated Albumin Bovine Serum Bovine Serum Albumin Serum Albumin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    D. Brackertz, G. F. Mitchell and I. R. Mackay,Antigen induced arthritis in mice. I. Induction of arthritis in various strains of mice, Arthritis Rheum.20, 841–850 (1977).PubMedGoogle Scholar
  2. [2]
    W. B. van den Berg, H. J. van Beusekom, L. B. A. van de Putte, W. A. Zwarts and M. van der Sluis,Antigen handling in antigen-induced arthritis in mice, Am. J. Pathol.108, 9–16 (1982).PubMedGoogle Scholar
  3. [3]
    W. B. van den Berg, L. B. A. van de Putte, W. A. Zwarts and L. A. B. Joosten,Electrical charge of the antigen determines intra-articular antigen handling and chronicity of arthritis in mice, J. Clin Invest.74, 1850–1859 (1984).PubMedGoogle Scholar
  4. [4]
    L. B. A. van de Putte, J. W. Lens, W. B. van den Berg and M. W. M. Kruysen,Exacerbation of antigen induced arthritis after challenge with intravenous antigen, Immunology49, 161–167 (1983).PubMedGoogle Scholar
  5. [5]
    J. W. Lens, W. B. van den Berg, L. B. A. van de Putte and L. van den Bresselaar,Flare-up of antigen-induced arthritis in mice after challenge with oral antigen, Clin. Exp. Immunol.58, 364–371 (1984).PubMedGoogle Scholar
  6. [6]
    I. S. Klasen, I. G. Donselaar, R. M. T. Ladestein, W. B. van den Berg and R. Benner,Joint inflammations and flare-up reactions in mice induced by a helper T cell clone, Agents and Actions19, 331–334 (1986).Google Scholar
  7. [7]
    M. H. Schreier, R. Tees, A. A. Nordin, R. Benner, A. T. J. Bianchi and M. J. van Zwieten,Functional aspects of helper T cell clones, Immunobiology161, 107–138 (1982).PubMedGoogle Scholar
  8. [8]
    N. N. Iscove,Culture of lymphocytes and hemopoietic cells in serum-free medium. InCell Culture Methods for Molecular and Cell Biology IV. Methods for Serum-Free Culture of Neuronal and Lymphoid Cells. (Eds. D. W. Barnes, D. A. Sirbasku and G. H. Sato) pp. 169–185, Allen R. Liss, New York 1984.Google Scholar
  9. [9]
    M. W. M. Kruysen, W. B. van den Berg, L. B. A. van de Putte and W. J. H. van den Broek,Detection and quantification of experimental joint inflammation in mice by measurement of 99m Tc-pertechnetate uptake, Agents and Actions11, 640–642 (1981).PubMedGoogle Scholar
  10. [10]
    M. O. Daily, C. G. Fathman, E. C. Butcher, E. Pillemer and I. L. Weissman,Abnormal migration of T lymphocyte clones, J. Immunol.128, 2134–2136 (1982).PubMedGoogle Scholar
  11. [11]
    I. S. Klasen, Th. H. van der Kwast, I. G. Donselaar, R. M. T. Ladestein and R. Benner,Flare-up of delayed type hypersensitivity initially induced by murine cloned helper T cells, Cell. Immunol.108, 235–241 (1987).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • I. S. Klasen
    • 2
  • R. M. T. Ladestein
    • 2
  • W. B. van den Berg
    • 1
  • R. Benner
    • 2
  1. 1.Department of RheumatologyUniversity Hospital St. RadboudNijmegenThe Netherlands
  2. 2.Department of Cell Biology, Immunology and GeneticsErasmus UniversityRotterdamThe Netherlands

Personalised recommendations