Agents and Actions

, Volume 23, Issue 1–2, pp 69–73 | Cite as

Flare up of joint inflammations induced by cloned helper T cells. Retention of the helper T cells

  • I. S. Klasen
  • R. M. T. Ladestein
  • W. B. van den Berg
  • R. Benner
Chondrocytes, Cartilage and Joint Damage


Joint inflammations were induced in mice by intra articular (ia) injection of cloned helper T cells specific for methylated bovine serum albumin (mBSA) together with mBSA. Local injection of mBSA several weeks after waning of a joint inflammation induced by cloned helper T cells caused a flare up reaction. This indicates that the helper T cells persisted in the joint after the primary inflammation. In the present paper we show that the helper T cells can also persist for some time in a knee joint in the absence of the specific antigen and/or an inflammatory reaction.


Methylated Albumin Bovine Serum Bovine Serum Albumin Serum Albumin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • I. S. Klasen
    • 2
  • R. M. T. Ladestein
    • 2
  • W. B. van den Berg
    • 1
  • R. Benner
    • 2
  1. 1.Department of RheumatologyUniversity Hospital St. RadboudNijmegenThe Netherlands
  2. 2.Department of Cell Biology, Immunology and GeneticsErasmus UniversityRotterdamThe Netherlands

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