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Antibacterial activity of the investigational oral and parenteral cephalosporin BK-218

  • New Antimicrobial Agents
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Abstract

BK-218 is a novel cephalosporin with a dual route of administration and spectrum of activity most similar to that of second-generation cephalosporins. BK-218 was active againstStreptococcus pneumoniae, Haemophilus influenzae andMoraxella catarrhalis but strains resistant to penicillins had higher MICs. BK-218 had greater activity (8-fold) than cefuroxime or cefaclor against oxacillin-susceptibleStaphylococcus spp. Moderate BK-218 activity was observed againstNeisseria gonorrhoeae and commonly isolatedEnterobacteriaceae such asEscherichia coli (MIC90, 1 mg/l),Klebsiella spp. (MIC90, 2 mg/l), andProteus mirabilis (MIC90, 2 mg/l). The following organisms were generally BK-218-resistant (MIC90, >16 mg/l):Bacteroides fragilis, Pseudomonas spp.,Acinetobacter spp.,Xanthomonas maltophilia, Citrobacter spp.,Enterobacter spp., indole-positiveProteus, Serratia spp., enterococci and oxacillin-resistant staphylococci.

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References

  1. Szabo I, Barabas J, Tar A, Kiss L, Filep M, Schmidt T, Morossy K, Toth-Martinez B, Barabas G, Hernadi F: In vitro investigation of BK-218, a new oral and parenteral cephalosporin. Antimicrobial Agents and Chemotherapy 1990, 34: 349–354.

    PubMed  Google Scholar 

  2. Jones RN, Gerlach EH, Fuchs PC: In vitro antimicrobial activity comparison of cefaclor (compound 99638), cephradine and cephalothin. Journal of Antibiotics 1977, 30: 753–755.

    PubMed  Google Scholar 

  3. Jones RN: Antimicrobial activity, spectrum and pharmacokinetics of old and new orally administered cephems. Antimicrobic Newsletter 1988, 5: 1–7.

    Article  Google Scholar 

  4. Kamimura T, Koho H, Matsumoto Y, Mine Y, Goto S, Kuwahara S: In vitro and in vivo antibacterial properties of FK 027, a new orally active cephem antibiotic. Antimicrobial Agents and Chemotherapy 1984, 25: 98–104.

    PubMed  Google Scholar 

  5. O'Callaghan CH, Sykes RB, Griffiths A, Thornton JE: Cefuroxime, a new cephalosporin antibiotic: activity in vitro. Antimicrobial Agents and Chemotherapy 1976, 9: 511–519.

    PubMed  Google Scholar 

  6. Guay DRP, Meatherall RC, Harding GK, Brown GR: Pharmacokinetics of cefixime (CL 284,635; FK 027) in healthy subjects and patients with renal insufficiency. Antimicrobial Agents and Chemotherapy 1986, 30: 483–490.

    Google Scholar 

  7. Bush K, Singer SB: Biochemical characteristics of extended broad spectrum beta-lactamases. Infection 1989, 17: 429–431.

    Article  PubMed  Google Scholar 

  8. Jacoby GA, Carreras I: Activities of β-lactam antibiotics againstEscherichia coli strains producing extended-spectrum β-lactamases. Antimicrobial Agents and Chemotherapy 1990, 34: 858–862.

    PubMed  Google Scholar 

  9. Jones RN, Barry AL: Susceptibility of stably derepressed beta-lactamase producing strains to imipenem and four quinolones. European Journal of Clinical Microbiology and Infectious Disease 1988, 7: 82–83.

    Article  Google Scholar 

  10. National Committee for Clinical Laboratory Standards: Standard methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-4. NCCLS, Villanova, PA, 1990.

    Google Scholar 

  11. National Committee for Clinical Laboratory Standards: Methods for antimicrobial susceptibility testing of anaerobic bacteria. Tentative standard MM-T2. NCCLS, Villanova, PA, 1989.

    Google Scholar 

  12. Jones RN, Gavan TL, Thornsberry C, Fuchs PC, Gerlach EH, Knapp JS, Murray P, Washington JA: Standardization of disk diffusion and agar dilution susceptibility tests forNeisseria gonorrhoeae: interpretive criteria and quality control guidelines for ceftriaxone, penicillin, spectinomycin and tetracycline. Journal of Clinical Microbiology 1989, 27: 2758–2766.

    PubMed  Google Scholar 

  13. Jorgensen JH, Redding JS, Maher LA, Howell AW: Improved medium for antimicrobial susceptibility testing ofHaemophilus influenzae. Journal of Clinical Microbiology 1987, 25: 2105–2113.

    PubMed  Google Scholar 

  14. Jorgensen HJ, Maher LA, Howell AW: Use ofHaemophilus test medium for broth microdilution antimicrobial susceptibility testing ofStreptococcus pneumoniae. Journal of Clinical Microbiology 1990, 28: 430–434.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Anti-infectives Research Center, Department of Pathology, University of Iowa College of Medicine, 52242, Iowa City, Iowa, USA

    D. M. Johnson & R. N. Jones

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  1. D. M. Johnson
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  2. R. N. Jones
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Johnson, D.M., Jones, R.N. Antibacterial activity of the investigational oral and parenteral cephalosporin BK-218. Eur. J. Clin. Microbiol. Infect. Dis. 11, 181–188 (1992). https://doi.org/10.1007/BF01967075

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