Radioimmunological determination of prostaglandin D2 after conversion to a stable degradation product
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Prostaglandin (PG)D2 was found to be unstable under various conditions. A radioimmunoassay for a stable degradation product of PGD2 formed by incubation at alkaline pH was developed. The radioimmunoassay is considerably more specific and sensitive than a comparable radioimmunoassay for PGD2. Using the radioimmunoassay for the stable degradation product release of large amounts of PGD2 from anaphylactic guinea-pig hearts was observed.
KeywordsProstaglandin Degradation Product Product Release Stable Degradation Radioimmunological Determination
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