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, Volume 15, Issue 1–2, pp 87–89 | Cite as

Radioimmunological determination of prostaglandin D2 after conversion to a stable degradation product

  • Klaus Lange
  • Bernhard A. Peskar
Inflammation and Anti-Inflammatories: Miscelaneous Studies


Prostaglandin (PG)D2 was found to be unstable under various conditions. A radioimmunoassay for a stable degradation product of PGD2 formed by incubation at alkaline pH was developed. The radioimmunoassay is considerably more specific and sensitive than a comparable radioimmunoassay for PGD2. Using the radioimmunoassay for the stable degradation product release of large amounts of PGD2 from anaphylactic guinea-pig hearts was observed.


Prostaglandin Degradation Product Product Release Stable Degradation Radioimmunological Determination 


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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • Klaus Lange
    • 1
  • Bernhard A. Peskar
    • 1
  1. 1.Institute of Pharmacology and ToxicologyRuhr-University BochumBochum 1FRG

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