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Ethane exhalation after carrageenan-induced pleurisy in rats

  • Oxygen Radical Generation by Phagocytes
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Abstract

Carrageenan-induced pleurisy in rats causes enhanced lipid peroxidation, measured by ethane evolutionin vivo. Ethane evolution was totally inhibited by SOD (100 U/rat), while Se-GSH·Px (100 U/rat) depressed ethane evolution to the basal level, when both enzymes were given intrathoracically 0.5 h after carrageenan.

GSH (20 mg/rat) had only slight effects, in contrast to Se-GSH·Px and GSH, injected together, which had no influence on ethane evolution.

These effects didn't correlate with other signs of acute inflammation, like exudate volume and leucocyte number, but they do indicate differing significance of reactive oxygen metabolites in and their scavengers on symptoms of inflammation.

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Authors and Affiliations

  1. Pharmacological Research, A. Nattermann & Cie. GmbH, PO Box 35 01 20, D-5000, Köln 30, FRG

    S. Leyck, E. Graf & G. Krebs

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  1. S. Leyck
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  2. E. Graf
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  3. G. Krebs
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Leyck, S., Graf, E. & Krebs, G. Ethane exhalation after carrageenan-induced pleurisy in rats. Agents and Actions 15, 50–51 (1984). https://doi.org/10.1007/BF01966961

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  • DOI: https://doi.org/10.1007/BF01966961

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