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Inhibition of transmitter release from isolated rabbit kidney by bradykinin

  • Histamine and Kinins
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Abstract

The effect of kallikrein on the release of norepinephrine has been studied in the isolated perfused rabbit kidney. Kallikrein in the perfusion medium caused an inhibition in the rise of the perfusion pressure induced by periarterial stimulation and in the contraction of rabbit aorta superfused by the venous outflow of the stimulated kidney. On the contrary, kallikrein caused a potentiation in the urine volume induced by periarterial stimulation. Similar findings were obtained when bradykinin was added instead of kallikrein. Kallikrein did not alter the pressure response and rabbit aorta contraction but potentiated the diuretic effects of exogenously administered norepinephrine. Acetyl salicyclic acid when added to the perfusion medium containing kallikrein caused a reversal in all parameters measured in this study.

It is concluded that the changes of the effects of periarterial stimulation of the isolated rabbit kidney by kallikrein are mediated through the bradykinin-mediated increased generation of intrarenal prostaglandins.

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References

  1. P. Hedqvist andÅ. Wennmalm,Comparison of the Effects of Prostaglandins E 1,E 2 and F 2a on the Sympathetically Stimulated Rabbit Heart, Acta Physiol. Scand.83, 156–162 (1971).

    Google Scholar 

  2. U.S. v.Euler andP. Hedqvist,Inhibitory Action of Prostaglandins E 1 and E 2 on the Neuromuscular Transmission in the Guinea-Pig vas deferens, Acta Physiol. Scand.77, 510–512 (1969).

    PubMed  Google Scholar 

  3. N. Gilmore, J.R. Vane andJ.H. Wyllie,Prostaglandins Release by the Spleen, Nature (London)218, 1135–1140 (1968).

    Google Scholar 

  4. P. Hedqvist,Control by Prostaglandin E 2 of Sympathetic Transmission in the Spleen, Life Sci.9 (1), 269–278 (1970).

    PubMed  Google Scholar 

  5. Z.S. Ercan,Changes Induced by Angiotensins and Prostaglandin E 2 on the Release of Transmitter from Isolated Perfused Rabbit Kidney During Periarterial Stimulation, Arch. int. Physiol. Biochim.83, 799–807 (1975).

    PubMed  Google Scholar 

  6. R.K. Türker andZ.S. Ercan,Effect of Prostaglandin E 2 on the Pressor Response to Periarterial Stimulation and Norepinephrine of the Isolated Perfused Rabbit Kidney, Prostaglandins9 (5), 695–701 (1975).

    PubMed  Google Scholar 

  7. K. Starke,Action of Angiotensin on Uptake, Release and Metabolism off 14 C-Noradrenaline by Isolated Rabbit Heart, Eu. J. Pharmacol.14, 112–123 (1971).

    Google Scholar 

  8. R.K. Türker,Effect of Angiotensin on the Response to Norepinephrine and Periarterial Stimulation of the Isolated Perfused Cat Terminal Ileum, Eu. J. Pharmacol.21, 171–177 (1973).

    Google Scholar 

  9. A. Nasjletti andJ.C. Chourio,Interaction of Mineralocorticoids Renal Prostaglandins and the Renal Kallikrein-Kinin System, Fed. Proc.35 (2), 189–193 (1976).

    PubMed  Google Scholar 

  10. Z.S. Ercan, R.K. Türker andT.A. Bökesoy,Effect of Asp 1 -B-amide-Val 5 -angiotensin II and (N,N-dimethyl)Gly 1 -Ile 5 -angiotensin II on the Isolated Perfused Rabbit Kidney, Arch. int. Pharmacodyn.211, 237–246 (1974).

    PubMed  Google Scholar 

  11. R.F. Furchgott andS. Bhadrakom,Reaction of Strips of Rabbit Aorta to Epinephrine Isopropyl Arterenol, Sodium Nitrate and Other Drugs, J. Pharmacol. Exp. Ther.108, 129–143 (1953).

    PubMed  Google Scholar 

  12. J.R. Vane,Use of Isolated Organs for Detecting Active Substance in the Circulating Bloods, Br. J. Pharmac.23, 360–373 (1964).

    Google Scholar 

  13. J.R. Vane,Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-Like Drugs, Nature (New Biol.)231, 232–235 (1971).

    Google Scholar 

  14. J.C. McGiff, K. Crowshan, N.A. Terragno, A.J. Lowigro, J.C. Strand, M.A. Williamson, J.B. Lee andK.K.F. Ng,Prostaglandin-Like Substance Appearing in Canine Renal Venous Blood During Renal Ischemia, Circ Res.27, 765–782 (1970).

    PubMed  Google Scholar 

  15. P.H. Chanh, M. Junstad andÅ. Wennmalm,Augmented Noradrenaline Release Following Nerve Stimulation after Inhibition of Prostaglandin Synthesis with Indomethacin, Acta Physiol Scand.86, 563–567 (1972).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, University of Ankara, Turkey

    R. Kazim Türker & Z. Sevim Ercan

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  1. R. Kazim Türker
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  2. Z. Sevim Ercan
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This work was supported by a grant from the Turkish Scientific and Technical Research Council (TAG-350).

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Türker, R.K., Ercan, Z.S. Inhibition of transmitter release from isolated rabbit kidney by bradykinin. Agents and Actions 7, 453–457 (1977). https://doi.org/10.1007/BF01966852

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  • DOI: https://doi.org/10.1007/BF01966852

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