Agents and Actions

, Volume 7, Issue 4, pp 447–451 | Cite as

Bradykinin action in the rat duodenum through the cyclic AMP system

  • I. Paegelow
  • S. Reissmann
  • G. Vietinghoff
  • W. Römer
  • H. Arold
Histamine and Kinins Research Reports


Activators of the adenylate cyclase or inhibitors of the cAMP-phosphodiesterase, respectively, potentiate the bradykinin-induced relaxation of the rat duodenum, whereas imidazole as a stimulator of the cAMP-phosphodiesterase reduces the relaxation. The experiments indicate a linkage between the adenylate cyclase system with the biological action of bradykinin on the rat duodenum. In contrast, no similar effect has been observed on the rat uterus.


Biological Action Imidazole Bradykinin Adenylate Cyclase Adenylate Cyclase System 
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Copyright information

© Birkhäuser-Verlag 1977

Authors and Affiliations

  • I. Paegelow
    • 1
    • 2
  • S. Reissmann
    • 1
    • 2
  • G. Vietinghoff
    • 1
    • 2
  • W. Römer
    • 1
    • 2
  • H. Arold
    • 1
    • 2
  1. 1.Department of Pharmacology and ToxicologyWilhelm-Pieck-UniversityRostockGDR
  2. 2.Department of Biology, Division of BiochemistryFriedrich-Schiller-UniversityJenaGDR

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