Agents and Actions

, Volume 14, Issue 1, pp 124–130 | Cite as

Influence of zinc, D-penicillamine and oxygen on poisoning withAmanita phalloides. Zinc accelerates liver regeneration and prevents the depletion of brain noradrenaline caused by the mushroom

  • G. L. Floersheim
  • L. Bianchi
  • A. Probst
  • N. Chiodetti
  • C. G. Honegger
Models in Toxicology

Abstract

Pretreatment with zinc aspartate increased the survival rate of mice poisoned with a lyophilisate from the mushroomAmanita phalloides (APL). In the livers of the zinc-treated animals, confluent necrosis was cleared earlier. Zinc also prevented the reduction of brain noradrenaline caused by the mushroom as well as the rise of brain dopamine and brain weight.d-Penicillamine also protected against the lethal effects of APL. The survival afforded by zinc pretreatment was marginally ameliorated by additional oxygenation.

Keywords

Oxygen Zinc Aspartate Survival Rate Dopamine 

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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • G. L. Floersheim
    • 1
  • L. Bianchi
    • 2
  • A. Probst
    • 2
  • N. Chiodetti
    • 1
  • C. G. Honegger
    • 1
  1. 1.Department of Surgery and ResearchZentrum für Lehre und ForschungBaselSwitzerland
  2. 2.Department of PathologyKantonsspitalBaselSwitzerland

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