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Decreased vascular sensitivity to histamine during aging

  • Histamine and Kinins
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Abstract

The sensitivity of thoracic aorta preparations to histamine decreased with age. The responsiveness to histamine was unchanged. Indomethacin (17 μM) did not affect the basal tone of preparations from either young or old guinea pigs nor did the drug alter aortic sensitivity or responsiveness to histamine. The data show that (a) changes in vascular sensitivity to histamine during aging are not due to prostaglandins and that (b) prostaglandins do not act locally to modulate vascular tissue response to histamine.

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Authors and Affiliations

  1. The John B. Pierce Foundation Laboratory, 290 Congress Avenue, 06519, New Haven, CT, USA

    C. Brink, P. G. Duncan & J. S. Douglas

Authors
  1. C. Brink
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  2. P. G. Duncan
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  3. J. S. Douglas
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Brink, C., Duncan, P.G. & Douglas, J.S. Decreased vascular sensitivity to histamine during aging. Agents and Actions 14, 8–10 (1984). https://doi.org/10.1007/BF01966826

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  • DOI: https://doi.org/10.1007/BF01966826

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